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Related Concept Videos

Pulmonary Hypertension: Classification and Pathogenesis01:30

Pulmonary Hypertension: Classification and Pathogenesis

880
Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
880
Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure01:16

Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure

787
Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home.
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
787
Pulmonary Function Tests01:25

Pulmonary Function Tests

1.1K
Pulmonary Function Tests (PFTs)
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...
1.1K
Factors Affecting Pulmonary Ventilation01:19

Factors Affecting Pulmonary Ventilation

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Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
3.8K
Gross Anatomy of the Lungs01:17

Gross Anatomy of the Lungs

6.5K
The lungs are a pair of vital organs connected to the trachea via the left and right bronchi. The base of these organs meets the dome-shaped muscle known as the diaphragm. Encased by the pleurae, the lungs contact the mediastinum. The right lung is shorter yet wider, and has a larger volume than the left lung. The left lung has an indentation known as the cardiac notch. The superior region of the lungs is referred to as the apex, whereas the base is the lower region near the diaphragm. The...
6.5K
Pulmonary Embolism I: Introduction01:29

Pulmonary Embolism I: Introduction

1.3K
Pulmonary embolism (PE) occurs when a thrombus, fat or air embolus, amniotic fluid, or tumor tissue blocks one or more pulmonary arteries. These blockages originate in the venous system or the right side of the heart.EtiologyPE primarily arises from deep vein thrombosis (DVT) and other hypercoagulable states, such as inherited thrombophilias. Additional etiological factors include venous stasis, commonly seen in obesity, and endothelial injury from surgery and trauma. Less common causes include...
1.3K

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Related Experiment Video

Updated: Apr 11, 2026

Increasing Pulmonary Artery Pulsatile Flow Improves Hypoxic Pulmonary Hypertension in Piglets
08:08

Increasing Pulmonary Artery Pulsatile Flow Improves Hypoxic Pulmonary Hypertension in Piglets

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Lung function in pulmonary hypertension.

A T Low1, A R L Medford2, A B Millar3

  • 1University Hospitals Bristol NHS Foundation Trust, Upper Maudlin Street, Bristol, United Kingdom.

Respiratory Medicine
|June 3, 2015
PubMed
Summary
This summary is machine-generated.

Pulmonary hypertension (PH) patients experience breathlessness due to airway abnormalities, not just cardiac issues. Further research into lung function changes and inflammation is needed for better patient management.

Keywords:
Congenital heart diseaseIdiopathic pulmonary arterial hypertensionInflammationLung function testsPulmonary arterial hypertensionPulmonary hypertension

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Left Atrial Stenosis Induced Pulmonary Venous Arterialization and Group 2 Pulmonary Hypertension in Rat
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Area of Science:

  • Pulmonary Medicine
  • Cardiology
  • Respiratory Physiology

Background:

  • Breathlessness is a common symptom in pulmonary hypertension (PH), impacting patient morbidity.
  • While cardiac remodelling is known, airway abnormalities in PH patients may also contribute to symptoms.
  • Current understanding of these airway changes is limited, with inconsistent findings across studies.

Purpose of the Study:

  • To review existing studies on airway abnormalities in major pulmonary hypertension groups.
  • To describe the utility of cardiopulmonary exercise testing in assessing pulmonary arterial hypertension (PAH).
  • To explore potential causes and the role of inflammation in lung function abnormalities in PH.

Main Methods:

  • Systematic review of studies on airway abnormalities in various PH classifications.
  • Analysis of cardiopulmonary exercise testing data to evaluate cardiopulmonary interaction during exercise in PAH.
  • Discussion of potential etiological factors and inflammatory mechanisms.

Main Results:

  • Conflicting findings exist regarding the nature and extent of airway abnormalities in PH.
  • Cardiopulmonary exercise testing offers insights into cardiopulmonary interactions during exertion in PAH.
  • The precise reasons for lung function abnormalities in PH remain unclear.

Conclusions:

  • Airway abnormalities are a potential contributor to breathlessness in pulmonary hypertension.
  • Further research is essential to elucidate the causes of lung function changes and inflammation.
  • Improved understanding will aid in optimizing the management of PH patients.