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Updated: Apr 11, 2026

Production and Visualization of Bacterial Spheroplasts and Protoplasts to Characterize Antimicrobial Peptide Localization
Published on: August 11, 2018
Ultrashort Antimicrobial Peptides with Antiendotoxin Properties
Ya-Han Chih1, Yen-Shan Lin1, Bak-Sau Yip2
1Institute of Biotechnology and Department of Medical Science, National Tsing Hua University, Hsinchu, Taiwan.
Abstract:
Release of lipopolysaccharide (LPS) (endotoxin) from bacteria into the bloodstream may cause serious unwanted stimulation of the host immune system. Some but not all antimicrobial peptides can neutralize LPS-stimulated proinflammatory responses. Salt resistance and serum stability of short antimicrobial peptides can be boosted by adding β-naphthylalanine to their termini. Herein, significant antiendotoxin effects were observed in vitro and in vivo with the β-naphthylalanine end-tagged variants of the short antimicrobial peptides S1 and KWWK.
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