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Updated: Apr 11, 2026

Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection
Published on: October 25, 2013
Increased Vancomycin Susceptibility in Mycobacteria: a New Approach To Identify Synergistic Activity against
Karine Soetaert1, Céline Rens2, Xiao-Ming Wang1
1Scientific Institute of Public Health (WIV-ISP), Operational Direction of Communicable and Infectious Diseases, Brussels, Belgium.
Abstract:
Mycobacterium tuberculosis is wrapped in complex waxes, impermeable to most antibiotics. Comparing Mycobacterium bovis BCG and M. tuberculosis mutants that lack phthiocerol dimycocerosates (PDIM) and/or phenolic glycolipids with wild-type strains, we observed that glycopeptides strongly inhibited PDIM-deprived mycobacteria. Vancomycin together with a drug targeting lipid synthesis inhibited multidrug-resistant (MDR) and extensively drug-resistant (XDR) clinical isolates. Our study puts glycopeptides in the pipeline of potential antituberculosis (TB) agents and might provide a new antimycobacterial drug-screening strategy.
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