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Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering
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Oleic acid surfactant in polycaprolactone/hydroxyapatite-composites for bone tissue engineering.

Guinea B C Cardoso1, Devid Maniglio2, Fabio Z Volpato2

  • 1University of Campinas, Materials Engineering Department, Faculty of Mechanical Engineering, Campinas, Brazil.

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
|June 3, 2015
PubMed
Summary

This study developed a new poly(ε-caprolactone) composite film with hydroxyapatite for bone tissue engineering. The film shows improved hydrophilicity and cell compatibility, offering potential for bone defect repair.

Keywords:
bone graftcomposite/hard tissuetissue engineering

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Polymer Chemistry

Background:

  • Bone defects from trauma, disease, or cancer require effective bone substitutes.
  • Autologous bone grafting has limitations including donor-site pain and limited supply.
  • Tissue engineering scaffolds must be biocompatible, biodegradable, and promote cell growth.

Purpose of the Study:

  • To develop and characterize a novel poly(ε-caprolactone) (PCL) composite film incorporating hydroxyapatite (HAp) using oleic acid (OA) as a dispersant.
  • To evaluate the physical, mechanical, and in vitro biological properties of the PCL/OA/HAp composite films for bone tissue engineering applications.

Main Methods:

  • Fabrication of PCL films with and without HAp, using OA as a surfactant.
  • Characterization using contact angle, scanning electron microscopy (SEM), atomic force microscopy (AFM), and tensile mechanical testing.
  • In vitro evaluation of cell adhesion and proliferation using U2OS human osteosarcoma cells.

Main Results:

  • Oleic acid enabled homogenous dispersion of hydroxyapatite within the poly(ε-caprolactone) matrix.
  • The PCL/OA/HAp films exhibited increased surface roughness and hydrophilicity compared to pure PCL.
  • While HAp addition increased brittleness (lower yield strength, higher tensile modulus), U2OS cells adhered and proliferated on all tested surfaces.

Conclusions:

  • The use of oleic acid effectively disperses hydroxyapatite in poly(ε-caprolactone) films.
  • The developed composite material shows promising characteristics for supporting bone regeneration.
  • Further investigation into this composite's potential for bone defect repair is warranted.