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Elevated heart rate predicts β cell function in non-diabetic individuals: the RISC cohort

Fabrice Bonnet1, Jean-Philippe Empana2, Andrea Natali2

  • 1Service Endocrinologie-DiabétologieCHU Rennes, Université Rennes 1, Rennes, FranceInserm Centre for research in Epidemiology and Population Health (CESP) U1018Villejuif, FranceParis Cardiovascular Research Centre (PARCC)INSERM UMRS 970, Paris, FranceDepartment of Internal MedicineUniversity of Pisa, Pisa, ItalyDepartment of Internal MedicineCardio-Diabetes and Core Lab, Diabetes Research Institute, IRCCS Ospedale San Raffaele, Milan, ItalyService d'enseignement thérapeutique pour maladies chroniquesHôpitaux Universitaires de Genève, Geneva, SwitzerlandFaculty of Medicine University of BelgradeClinic for Endocrinology, Diabetes and Metabolic Diseases, Belgrade, SerbiaDepartment of Epidemiology and BiostatisticsEMGO Institute for Health and Care Research, Amsterdam, The NetherlandsC N R Institute of NeurosciencePadova, Italy Service Endocrinologie-DiabétologieCHU Rennes, Université Rennes 1, Rennes, FranceInserm Centre for research in Epidemiology and Population Health (CESP) U1018Villejuif, FranceParis Cardiovascular Research Centre (PARCC)INSERM UMRS 970, Paris, FranceDepartment of Internal MedicineUniversity of Pisa, Pisa, ItalyDepartment of Internal MedicineCardio-Diabetes and Core Lab, Diabetes Research Institute, IRCCS Ospedale San Raffaele, Milan, ItalyService d'enseignement thérapeutique pour maladies chroniquesHôpitaux Universitaires de Genève, Geneva, SwitzerlandFaculty of Medicine University of BelgradeClinic for Endocrinology, Diabetes and Metabolic Diseases, Belgrade, SerbiaDepartment of Epidemiology and BiostatisticsEMGO Institute for Health and Care Research, Amsterdam, The NetherlandsC N R Institute of NeurosciencePadova, Italy fabrice.bonnet@chu-rennes.fr.

European Journal of Endocrinology
|June 3, 2015
PubMed
Summary

Higher resting heart rate in non-diabetic adults predicts future impaired glucose regulation and reduced beta-cell function, independent of insulin sensitivity. This suggests a potential role for the sympathetic nervous system in beta-cell dysfunction.

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