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CCR 20th Anniversary Commentary: Determining a Pharmacokinetic/Pharmacodynamic Relationship for Sunitinib—A Look Back

Dirk B Mendel1, Julie M Cherrington2, A Douglas Laird3

  • 1Translational Medicine, MedImmune, LLC, Gaithersburg, Maryland.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
|June 3, 2015
PubMed

Insights

Researchers established exposure guidelines for sunitinib, a cancer therapy drug. This preclinical study identified a biologically active dose for early clinical trials of the receptor tyrosine kinase inhibitor.

Area of Science:

  • Oncology
  • Pharmacology
  • Translational Research

Background:

  • Sunitinib is a multitargeted receptor tyrosine kinase inhibitor investigated for cancer therapy.
  • Understanding the exposure-activity relationship is crucial for effective drug development.

Observation:

  • Mendel and colleagues developed a preclinical approach to assess sunitinib's exposure-activity relationship.
  • The study focused on identifying a biologically active dose for clinical trials.

Findings:

  • The research successfully established exposure guidelines for sunitinib.
  • This work provided a foundation for determining appropriate dosing in early-phase oncology trials.

Implications:

  • The findings facilitate the rational design of clinical trials for sunitinib.
  • This approach can be applied to other novel oncology therapeutics.
  • Optimizing exposure-activity relationships enhances the potential efficacy of cancer drugs.

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