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Tissue Engineering of the Intestine in a Murine Model
Published on: December 1, 2012
Surgical strategies in paediatric inflammatory bowel disease
Colin T Baillie1, Jennifer A Smith1
1Colin T Baillie, Jennifer A Smith, Department of Paediatric Surgery, Royal Liverpool Childrens Hospital, NHS Trust, Liverpool L12 2AP, United Kingdom.
Abstract:
Inflammatory bowel disease (IBD) comprises two distinct but related chronic relapsing inflammatory conditions affecting different parts of the gastrointestinal tract. Crohn's disease is characterised by a patchy transmural inflammation affecting both small and large bowel segments with several distinct phenotypic presentations. Ulcerative colitis classically presents as mucosal inflammation of the rectosigmoid (distal colitis), variably extending in a contiguous manner more proximally through the colon but not beyond the caecum (pancolitis). This article highlights aspects of the presentation, diagnosis, and management of IBD that have relevance for paediatric practice with particular emphasis on surgical considerations. Since 25% of IBD cases present in childhood or teenage years, the unique considerations and challenges of paediatric management should be widely appreciated. Conversely, we argue that the organizational separation of the paediatric and adult healthcare worlds has often resulted in late adoption of new approaches particularly in paediatric surgical practice.
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