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Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation01:30

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation

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Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
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Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

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Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
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Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

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Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
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Related Experiment Video

Updated: Apr 11, 2026

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection
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Persistent and Recurrent Clostridium difficile Colitis.

Shola A Cole1, Thomas J Stahl2

  • 1Section of Colon and Rectal Surgery, MedStar Washington Hospital Center, Washington, District of Columbia.

Clinics in Colon and Rectal Surgery
|June 3, 2015
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Summary
This summary is machine-generated.

Clostridium difficile infection (CDI) causes frequent hospital-acquired diarrhea and can be fatal. New treatments are emerging, but more research is needed for persistent and recurrent cases.

Keywords:
BI/NAP1/027fecal microbiota therapyrecurrent Clostridium difficile

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Area of Science:

  • Infectious Diseases
  • Gastroenterology
  • Hospital Epidemiology

Background:

  • Clostridium difficile infection (CDI) is a leading cause of nosocomial diarrhea.
  • CDI presents a significant therapeutic challenge, leading to increased morbidity and mortality.
  • Persistent and recurrent CDI complicates eradication efforts.

Purpose of the Study:

  • To review current treatment strategies for CDI.
  • To highlight the need for novel therapeutics in managing recurrent CDI.
  • To emphasize the necessity of further clinical trials for treatment protocols.

Main Methods:

  • Literature review of existing studies on CDI treatment.
  • Analysis of current therapeutic approaches and emerging treatments.
  • Discussion of challenges in managing persistent and recurrent CDI.

Main Results:

  • CDI remains a significant healthcare-associated infection.
  • Existing treatments face challenges with persistent and recurrent infections.
  • Novel therapeutics are under development to address treatment resistance.

Conclusions:

  • Effective management of persistent and recurrent CDI requires further investigation.
  • Clinical trials are essential to establish optimal treatment protocols.
  • Advancing CDI treatment is critical to reduce patient morbidity and mortality.