Related Experiment Video
Updated: Apr 11, 2026

Intestinal Stem Cell Isolation and Culture in a Porcine Model of Segmental Small Intestinal Ischemia
Published on: May 18, 2018
Ischemic colitis
James F FitzGerald1, Luis O Hernandez Iii1
1Section of Colon and Rectal Surgery, MedStar Washington Hospital Center, Washington, District of Columbia.
Insights
Ischemic colitis is often linked to older individuals with heart issues. However, it can affect younger patients due to various factors, complicating diagnosis and treatment.
Area of Science:
- Gastroenterology
- Vascular Medicine
Background:
- Ischemic colitis is commonly associated with elderly patients and cardiovascular comorbidities.
- However, the condition can manifest in younger individuals with distinct risk factors, posing diagnostic challenges.
Purpose of the Study:
- To highlight the varied presentations of ischemic colitis beyond the typical elderly demographic.
- To underscore the diagnostic difficulties and management considerations in younger patients.
Main Methods:
- Review of clinical presentations and risk factors associated with ischemic colitis.
- Analysis of treatment outcomes, including medical management and surgical intervention.
Main Results:
- While most cases occur in the elderly with cardiovascular disease, younger patients present with different risk factors.
- A significant portion (approximately 20%) of patients require surgery, which carries substantial morbidity and mortality risks.
Conclusions:
- Ischemic colitis diagnosis requires consideration of diverse patient populations and risk factors.
- Effective management strategies are crucial, as surgical intervention is associated with poor outcomes.
Abstract:
Most clinicians associate ischemic colitis with elderly patients who have underlying cardiovascular comorbidities. While the majority of cases probably occur in this population, the disease can present in younger patients as a result of different risk factors, making the diagnosis challenging. While a majority of patients respond to medical management, surgery is required in approximately 20% of the cases and is associated with high morbidity and mortality.
Related Concept Videos
Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Drugs for Treatment of Ulcerative Colitis in IBD
Inflammatory Bowel Disease V: Surgical Management
Here are some common surgical interventions for IBD:

