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Related Experiment Video

Updated: Apr 11, 2026

Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice
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Acute colonic pseudoobstruction.

Allen P Chudzinski1, Earl V Thompson2, Jennifer M Ayscue3

  • 1Colorectal Surgery Program, Department of Surgery, MedStar Georgetown University Hospital, Washington, District of Columbia.

Clinics in Colon and Rectal Surgery
|June 3, 2015
PubMed
Summary
This summary is machine-generated.

Acute colonic pseudoobstruction (ACPO), or Ogilvie syndrome, involves severe colon distension without blockage. Prompt diagnosis and treatment, ranging from medical therapy to surgery, are crucial to prevent complications like ischemia and perforation.

Keywords:
Ogilvie syndromeacute colonic pseudoobstructioncolonic ileuslarge bowel obstruction

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Area of Science:

  • Gastroenterology
  • Colorectal Surgery

Background:

  • Acute colonic pseudoobstruction (ACPO), known as Ogilvie syndrome, is characterized by significant colonic distension without mechanical blockage.
  • Untreated ACPO can lead to severe complications, including bowel ischemia and perforation.

Purpose of the Study:

  • To review the epidemiology and pathophysiology of ACPO.
  • To outline the clinical presentation and diagnostic methods for ACPO.
  • To describe current treatment strategies for ACPO.

Main Methods:

  • Literature review of epidemiological data and pathophysiologic theories.
  • Analysis of clinical presentation and diagnostic modalities.
  • Summary of treatment options, including conservative, endoscopic, and surgical approaches.

Main Results:

  • ACPO presents as acute megacolon, primarily in adults, without evidence of obstruction.
  • Diagnosis relies on clinical signs, imaging, and exclusion of mechanical causes.
  • Treatment varies based on severity, from conservative management to subtotal colectomy.

Conclusions:

  • ACPO is a serious condition requiring timely recognition and management.
  • A multimodal approach to treatment is often necessary.
  • Understanding ACPO's epidemiology and pathophysiology aids in effective patient care.