Protective effect of salep on liver

Area of Science:

• Pharmacology
• Hepatology
• Natural Products Research

Background:

• Salep is utilized in food and traditional medicine.
• Its impact on liver health necessitates scientific evaluation.

Purpose of the Study:

• To investigate the effects of salep on liver function and tissue in an experimental model.
• To assess the hepatoprotective potential of salep extract.

Main Methods:

• Wistar rats were administered varying doses of salep intraperitoneally (20, 40, 80 mg/kg) alongside control and placebo groups.
• Liver enzymes, malondialdehyde (MDA), total oxidation capacity (TOC), and total antioxidant capacity (TAC) were measured after one month.
• Liver tissue was also evaluated to assess treatment effects.

Main Results:

• Salep administration led to a significant decrease in liver enzymes, MDA, and TOC levels.
• A significant increase in TAC was observed across different salep concentrations.
• Elevated total protein and albumin levels were noted in salep-treated groups.

Conclusions:

• Salep extract demonstrated a protective effect on the liver by modulating oxidative stress markers and improving key protein levels.
• The findings suggest salep possesses hepatoprotective properties.
• Salep may hold potential as a therapeutic agent for individuals suffering from liver ailments.