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Updated: Apr 11, 2026

An In Ovo Model for Testing Insulin-mimetic Compounds
Published on: April 23, 2018
QSAR study of some anti-hyperglycaemic sulphonylurea drugs
J C Dearden1, M Hewitt, P H Rowe
1a School of Pharmacy & Biomolecular Sciences, Liverpool John Moores University , Liverpool , UK.
Abstract:
Sulphonylureas are widely used anti-hyperglycaemic drugs for the treatment of type 2 diabetes. The only published quantitative structure-activity relationship (QSAR) models for sulphonylurea drugs have been found to be questionable, for a number of reasons. We have re-analysed the human anti-hyperglycaemic potencies, acute mouse intraperitoneal toxicities (LD50) and plasma protein-binding abilities of the 15 drugs using multiple linear regression and obtained good QSAR models for each endpoint. The obtained QSARs all comply well with the Organisation for Economic Co-operation and Development (OECD) Guidelines for the Validation of (Q)SARs. We could not carry out external validation of our models for acute toxicity and plasma protein-binding because of the very small datasets available.
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