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Published on: February 17, 2022
Elotuzumab Therapy for Relapsed or Refractory Multiple Myeloma
Sagar Lonial1, Meletios Dimopoulos, Antonio Palumbo
1From Winship Cancer Institute, Emory University School of Medicine, Atlanta (S.L.); National and Kapodistrian University of Athens, Athens (M.D.); A.O.U. San Giovanni Battista di Torino-Ospedale Molinette, Turin, Italy (A.P.); QEII Health Science Center and Dalhousie University, Halifax, NS (D.W.), Cross Cancer Institute and University of Alberta, Edmonton (A.B.), and Princess Margaret Cancer Centre, Toronto (D.R.) - all in Canada; Silesian Medical University, Katowice (S.G.), and Medical University of Lublin, Lublin (A.W.-C.) - both in Poland; Charles University Hospital, Prague, Czech Republic (I.S.); University Hospital, Nantes, France (P.M.); Complejo Asistencial Universitario de Salamanca-Instituto de Investigación Biomédica de Salamanca, Salamanca (M.-V.M.), and Clinica Universidad de Navarra-Centro de Investigación Médica Aplicada, Instituto de Investigación Sanitaria de Navarra, Pamplona (J.S.-M.) - both in Spain; Davidoff Cancer Center, Rabin Medical Center, Petah Tikva, and Tel Aviv University, Ramat Aviv - both in Israel (H.M.); Ankara University, Ankara, Turkey (M.B.); Alfred Health-Monash University, Melbourne, VIC, Australia (A. Spencer); Barts and the London NHS Trust, London (H.O.); University of Texas M.D. Anderson Cancer Center, Houston (R.Z.O.); Kyoto Prefectural University of Medicine, Kyoto (M.T.), and Nishigunma National Hospital, Shibukawa (M.M.) - both in Japan; Universitätsklinikum der Technische Universität, Dresden (C.R.), and Universitätsklinikum Würzburg, Würzburg (H.E.) - both in Germany; Zeikenhuis Netwerk Antwerpen (ZNA) Stuivenberg, Antwerp, Belgium (K.L.W.); AbbVie Biotherapeutics, Redwood City, CA (A. Singhal); Bristol-Myers Squibb, Princeton, NJ (J.K.), Wallingford, CT (E.B.), and Braine-l'Alleud, Belgium (V.P.); and Dana-Farber Cancer Institute, Boston (K.C.A., P.R.).
Adding elotuzumab to lenalidomide and dexamethasone significantly improved progression-free survival in patients with relapsed or refractory multiple myeloma. This combination therapy reduced the risk of disease progression or death by 30%.
Area of Science:
- Oncology
- Immunotherapy
Background:
- Elotuzumab is an immunostimulatory monoclonal antibody targeting signaling lymphocytic activation molecule F7 (SLAMF7).
- Previous studies indicated elotuzumab activity in combination regimens for multiple myeloma.
Purpose of the Study:
- To evaluate the efficacy and safety of elotuzumab plus lenalidomide and dexamethasone versus lenalidomide and dexamethasone alone in patients with relapsed or refractory multiple myeloma.
Main Methods:
- A phase 3 randomized controlled trial (ELOQUENT-2) was conducted.
- Patients received either elotuzumab, lenalidomide, and dexamethasone, or lenalidomide and dexamethasone alone.
- Progression-free survival and overall response rate were coprimary end points.
Main Results:
- Elotuzumab combination therapy demonstrated superior progression-free survival at 1 and 2 years compared to the control group.
- Median progression-free survival was 19.4 months with elotuzumab versus 14.9 months without (HR 0.70, P<0.001).
- Overall response rate was significantly higher in the elotuzumab group (79% vs. 66%, P<0.001).
- Common adverse events included lymphocytopenia, neutropenia, fatigue, and pneumonia; infusion reactions were infrequent.
Conclusions:
- Combination therapy with elotuzumab, lenalidomide, and dexamethasone significantly reduces the risk of disease progression or death in relapsed/refractory multiple myeloma.
- Elotuzumab offers a valuable treatment option for patients with relapsed or refractory multiple myeloma.
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