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Dynamic Layer-by-Layer Films: A Platform for Zero-Order Release.

Ya-Nan Zhao1, Qingping Yuan1, Chong Li1

  • 1State Key Laboratory of Medicinal Chemical Biology and Key Laboratory of Functional Polymer Materials, Institute of Polymer Chemistry, College of Chemistry, Nankai University, and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300071, China.

Biomacromolecules
|June 3, 2015
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Summary
This summary is machine-generated.

Achieving zero-order drug release is now possible using dynamic layer-by-layer (LBL) films. These films release drugs via interpolymer complex dissociation, offering controlled and intelligent drug delivery.

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Area of Science:

  • Polymer Science
  • Materials Science
  • Drug Delivery Systems

Background:

  • Zero-order drug release is a critical but challenging goal in controlled release systems.
  • Previous attempts have faced limitations in achieving consistent zero-order kinetics.

Purpose of the Study:

  • To investigate the potential of dynamic layer-by-layer (LBL) films for achieving perfect zero-order drug release.
  • To explore the mechanism and influencing factors of drug release from these dynamic LBL films.

Main Methods:

  • Fabrication of dynamic layer-by-layer (LBL) films using P(AAm-3-AAPBA) and PVA with narrow molecular weight distributions.
  • Characterization of drug release kinetics from the LBL films.
  • Investigation of release mechanisms, focusing on interpolymer complex dissociation rather than diffusion or degradation.
  • Evaluation of the influence of polymer molecular weight and external stimuli (pH, temperature, glucose) on release rates.

Main Results:

  • The dynamic LBL films demonstrated perfect zero-order release kinetics for P(AAm-3-AAPBA).
  • Drug release occurred through the dissociation of interpolymer complexes, not diffusion or degradation.
  • Release rate was found to be dependent on the molecular weight of the constituent polymers.
  • The release rate could be modulated by external environmental stimuli such as pH, temperature, and glucose concentration.

Conclusions:

  • Dynamic LBL films offer a novel platform for achieving zero-order drug release.
  • The mechanism of release via interpolymer complex dissociation provides a pathway for precise control.
  • These films enable not only zero-order but also intelligent, stimulus-responsive drug release.