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Metal-Ligand Bonds02:51

Metal-Ligand Bonds

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The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
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Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...
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Coordination Compounds and Nomenclature02:54

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In most main group element compounds, the valence electrons of the isolated atoms combine to form chemical bonds that satisfy the octet rule. For instance, the four valence electrons of carbon overlap with electrons from four hydrogen atoms to form CH4. The one valence electron leaves sodium and adds to the seven valence electrons of chlorine to form the ionic formula unit NaCl (Figure 1a). Transition metals do not normally bond in this fashion. They primarily form coordinate covalent bonds, a...
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Stereoisomerism02:52

Stereoisomerism

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Isomerism in Complexes
Isomers are different chemical species that have the same chemical formula.
Transition metal complexes often exist as geometric isomers, in which the same atoms are connected through the same types of bonds but with differences in their orientation in space. Coordination complexes with two different ligands in the cis and trans positions from a ligand of interest form isomers. For example, the octahedral [Co(NH3)4Cl2]+ ion has two isomers (Figure 1) In the cis...
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Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR
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Allosteric supramolecular coordination constructs.

Alejo M Lifschitz1, Mari S Rosen1, C Michael McGuirk1

  • 1Department of Chemistry and The International Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, United States.

Journal of the American Chemical Society
|June 3, 2015
PubMed
Summary
This summary is machine-generated.

The weak-link approach (WLA) in coordination chemistry enables the creation of stimuli-responsive supramolecular frameworks. These systems mimic biological allosteric enzymes, allowing tunable activity through small molecule recognition.

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Area of Science:

  • Coordination chemistry
  • Supramolecular chemistry
  • Inorganic chemistry

Background:

  • Coordination chemistry generates unique environments in supramolecular constructs to modify component properties.
  • Stimuli-responsive biological structures, like allosteric enzymes, inspire changes in supramolecular structure.
  • The weak-link approach (WLA) is a key strategy for synthesizing switchable supramolecular systems.

Purpose of the Study:

  • To provide a comprehensive description of the fundamental inorganic reactions underpinning WLA complex synthesis.
  • To explore the application of biological regulatory strategies to allosteric supramolecular design.
  • To highlight the development of WLA-based systems for catalysis, electron transfer, molecular recognition, sensing, and signal amplification.

Main Methods:

  • Utilizing the weak-link approach (WLA) with hemilabile ligands and transition metal centers.
  • Employing dynamic ligand sorting processes for post-assembly structural toggling.
  • Synthesizing multi-component frameworks with spatial definition and stimuli-responsiveness.

Main Results:

  • WLA enables post-assembly control over supramolecular framework structure via simple chemical reactions.
  • This approach yields spatially defined, stimuli-responsive, multi-component frameworks in high yields.
  • Functional systems mimicking allosteric enzymes have been developed, responding to small molecule inputs.

Conclusions:

  • The WLA is a versatile and generalizable strategy in inorganic chemistry for creating advanced functional materials.
  • Applying biological regulatory principles to WLA constructs allows for precise control over catalytic and electronic properties.
  • WLA-based supramolecular constructs offer significant potential in sensing, signal amplification, and molecular receptor design.