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Centrifugation

Centrifugation

Centrifugation is a separation technique based on differences in density or size. It is commonly used to separate solids from aqueous interferents. During centrifugation, the sample is placed in centrifugation tubes and spun at high angular velocity, which allows centrifugal force to act differentially on the different densities or masses of the components. After spinning, the supernatant liquid is decanted. Depending on the specific application, either the pellet or the supernatant is retained...

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Updated: Apr 11, 2026

Pneumatically Driven Microfluidic Platform for Micro-Particle Concentration

Pneumatically Driven Microfluidic Platform for Micro-Particle Concentration

Published on: February 1, 2022

Centrifugal microfluidic platforms: advanced unit operations and applications.

O Strohmeier¹, M Keller, F Schwemmer

¹Hahn-Schickard, Georges-Koehler-Allee 103, 79110 Freiburg, Germany. Nils.Paust@Hahn-Schickard.de.

Chemical Society Reviews

|June 3, 2015

Summary

This summary is machine-generated.

Centrifugal microfluidics offers advanced automation for laboratory workflows through integrated unit operations. This technology enables efficient liquid handling, miniaturization, and parallelization for diverse diagnostic and analytical applications.

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Area of Science:

Microfluidics
Biotechnology
Analytical Chemistry

Background:

Centrifugal microfluidics is a mature technology with widespread applications in diagnostics and analysis.
Major diagnostic companies are actively developing or marketing centrifugal microfluidic products.
The field is rapidly evolving with new fluidic functions and applications emerging.

Purpose of the Study:

To provide a comprehensive overview of centrifugal microfluidic unit operations.
To introduce the concept of "process chains" for automating laboratory workflows.
To analyze how novel unit operations enhance integration of complex applications.

Main Methods:

Review of existing centrifugal microfluidic unit operations.
Analysis of "process chain" integration for laboratory automation.
Evaluation of novel unit operations for advanced applications.

Main Results:

Centrifugal microfluidics enables pulse-free liquid propulsion, eliminating external pumps.
Scalable processing volumes from nanoliters to milliliters are achievable.
Efficient separation and bubble removal are facilitated by adjustable centrifugal forces.

Conclusions:

Centrifugal microfluidics integrates essential unit operations like transport, metering, mixing, and valving.
The technology supports automated liquid handling, miniaturization, parallelization, and assay integration.
Novel unit operations, such as pneumatic energy storage, expand application possibilities.