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Related Experiment Videos

Upper jaw in human cyclopia.

P McGrath1

  • 1Department of Anatomy, University of Sydney, Australia.

Acta Anatomica
|January 1, 1989
PubMed
Summary
This summary is machine-generated.

Human cyclopia results in a solid upper jaw due to fused facial bones. This study examines the skeletal contributions of the lacrimal, maxillae, and palatine bones in cyclopic facial development.

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Area of Science:

  • Developmental biology
  • Craniofacial anatomy
  • Medical genetics

Background:

  • Cyclopia is a severe congenital anomaly characterized by a single median orbit.
  • The upper jaw in cyclopia presents as a fused bony mass between the orbit and oral cavity.
  • Understanding the skeletal development of the cyclopic upper jaw is crucial for comprehending craniofacial malformations.

Purpose of the Study:

  • To investigate the specific skeletal elements forming the upper jaw in human cyclopia.
  • To analyze the contributions of the lacrimal, maxillae, and palatine bones to the cyclopic upper jaw.
  • To consider the impact of absent frontonasal process and nasal cavity on upper jaw formation in cyclopia.

Main Methods:

  • Serial sectioning of three perinatal human cyclopic heads (sagittal and coronal planes).

Related Experiment Videos

  • Examination of a dried cyclops skull.
  • Analysis of a desiccated cyclops head with orbital roof removal.

    • Main Results:

    • The study identified specific contributions of the lacrimal, maxillae, and palatine bones to the fused upper jaw structure.
    • Observations detailed the bony mass formation between the median orbit and oral cavity.
    • The absence of frontonasal process and nasal cavity influences on upper jaw development were considered.

    Conclusions:

    • The lacrimal, maxillae, and palatine bones play significant roles in forming the unique upper jaw structure in human cyclopia.
    • The findings provide insights into the skeletal basis of cyclopia and associated craniofacial abnormalities.
    • Further research can explore the genetic and developmental pathways underlying these malformations.