Liver depurative techniques: a single liver transplantation center experience

Area of Science:

• Hepatology
• Transplant Surgery
• Critical Care Medicine

Background:

• This study evaluated treatments with Prometheus in a liver transplant (LT) center.
• The primary outcomes assessed were 1-month and 6-month survival rates.

Purpose of the Study:

• To identify key factors influencing patient survival following Prometheus treatment in a liver transplant setting.
• To analyze the association of demographic, laboratorial, and clinical data with short-term and mid-term outcomes.

Main Methods:

• A cohort of 64 patients treated with Prometheus was analyzed.
• Data included patient demographics, liver enzymes, ammonia levels, Model for End-Stage Liver Disease (MELD) score, and Child-Turcotte-Pugh (CTP) score.
• Multivariate analysis was employed to determine independent predictors of survival.

Main Results:

• Overall mortality was 35.9% during hospitalization. Liver transplantation (LT) was performed in 31.3% of patients.
• Older age, higher international normalized ratio (INR), and acute liver failure (ALF) were associated with adverse 1-month outcomes.
• Older age and acute kidney injury (AKI) were linked to worse 6-month outcomes.

Conclusions:

• Older age is a critical predictor for both 1-month and 6-month survival.
• Higher INR and ALF significantly impact 1-month survival, while AKI affects 6-month survival.
• No significant survival difference was observed between patients who underwent LT and those who did not.