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Modeling Alcohol Consumption in Rodents Using Two-Bottle Choice Home Cage Drinking and Microstructural Analysis

Modeling Alcohol Consumption in Rodents Using Two-Bottle Choice Home Cage Drinking and Microstructural Analysis

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Microstructural analysis of rat ethanol and water drinking patterns using a modified operant self-administration

Stacey L Robinson¹, Brian A McCool²

¹Department of Physiology & Pharmacology, Wake Forest School Medicine, Winston-Salem, NC, United States; Neuroscience and Alcohol Research Training Programs, Wake Forest School Medicine, Winston-Salem, NC, United States.

Physiology & Behavior

|June 4, 2015

Summary

This study refined an operant rodent model for analyzing ethanol drinking patterns, revealing how ethanol vapor exposure and SR141716a impact consumption microstructures. Microstructural analysis offers insights into alcohol use disorder mechanisms.

Keywords:

Drinking pattern Ethanol Ethanol vapor Microstructure Operant self-administration

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Microdialysis of Ethanol During Operant Ethanol Self-administration and Ethanol Determination by Gas Chromatography

Microdialysis of Ethanol During Operant Ethanol Self-administration and Ethanol Determination by Gas Chromatography

Published on: September 5, 2012

Area of Science:

Neuroscience
Behavioral Pharmacology
Addiction Research

Background:

Ethanol drinking patterns are crucial in alcohol use disorders (AUDs).
Understanding these patterns requires refined animal models.
Operant rodent models allow for detailed analysis of ethanol consumption behaviors.

Purpose of the Study:

To refine an operant rodent model for microstructural analysis of ethanol consumption.
To evaluate the effects of ethanol vapor exposure and a cannabinoid receptor antagonist (SR141716a) on drinking patterns.
To investigate alterations in appetitive and consummatory behaviors related to ethanol intake.

Main Methods:

Male Long-Evans rats were trained on a fixed-ratio (FR1) operant paradigm with continuous liquid access.
Drinking microstructure (bout size, duration, lick patterns) was assessed for ethanol and water.
Effects of chronic intermittent ethanol vapor exposure and SR141716a administration were evaluated.

Main Results:

Ethanol vapor exposure increased ethanol-directed responding, total consumption, and intake rate.
Differential changes in ethanol and water bout size, duration, and lick patterns were observed.
SR141716a administration reversed many of the observed effects of ethanol vapor exposure.

Conclusions:

Microstructural analysis in operant rodent models is a powerful tool for studying ethanol drinking patterns.
This approach provides translational insights into neural mechanisms underlying specific components of drug consumption.
The refined model aids in understanding the complexities of alcohol consumption and AUDs.