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The Association of BDNF Val66Met Polymorphism With Trait Anxiety in Panic Disorder

Yoshiaki Konishi¹, Hisashi Tanii¹, Takeshi Otowa¹

¹From the Dept. of Psychiatry, Division of Neuroscience, Graduate School of Medicine, Brain Science and Animal Model Research Center, Mie University, Mie, Japan (YK, HT, MO); the Dept. of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan (TO); the Laboratory of Health Education, Graduate School of Education, University of Tokyo, Tokyo, Japan (TS); the Research Center for Panic Disorder, Nagoya Mental Clinic, Nagoya, Japan (HK); and the Dept. of Psychiatry, Tokyo Metropolitan Matsuzawa Hospital, Tokyo, Japan (YO).

The Journal of Neuropsychiatry and Clinical Neurosciences

|June 4, 2015

Abstract:

Recent studies indicate that early-onset panic disorder (PD) may show distinct clinical characteristics. The authors compared patients with early-onset PD, patients with late-onset PD, and healthy control subjects in terms of brain-derived neurotrophic factor (BDNF), the Val66Met polymorphism, State-Trait Anxiety Inventory (STAI) scores, and the Revised NEO Personality Inventory. In patients with early-onset PD, the STAI-T score was high in the Met/Met group, whereas the STAI-T score of the Val/Val group tended to be higher for healthy control subjects. The conflicting effect of the BDNF genotype between patients with early-onset PD and healthy control subjects suggests that the BDNF Met/Met genotype may increase trait anxiety in early-onset PD.

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