Related Experiment Video

Updated: Apr 11, 2026

Creating Virtual-hand and Virtual-face Illusions to Investigate Self-representation
06:53

Creating Virtual-hand and Virtual-face Illusions to Investigate Self-representation

Published on: March 1, 2017

14.0K

Two Faces of SIVA

Lois Resnick-Silverman1, James J Manfredi2

  • 1Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York.

Cancer Discovery
|June 4, 2015
PubMed

Insights

In non-small cell lung cancer, the gene SIVA promotes tumor growth by activating mTOR signaling. Inhibiting SIVA in mice stopped tumor development, suggesting SIVA as a potential therapeutic target for lung cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Genetics

Background:

  • Non-small cell lung cancer (NSCLC) with KRAS mutations presents limited therapeutic options.
  • The p53 tumor suppressor pathway plays a critical role in apoptosis and cancer progression.
  • SIVA is a known p53 target gene involved in regulating apoptosis.

Purpose of the Study:

  • To investigate the role of SIVA in KRAS-mutated NSCLC.
  • To determine the mechanism by which SIVA promotes tumorigenesis.
  • To evaluate SIVA as a potential therapeutic target for NSCLC.

Main Methods:

  • Analysis of SIVA expression in NSCLC cell lines with mutated KRAS.
  • Investigating the p53-independent regulation of SIVA.
  • Studying the impact of SIVA on mTOR signaling pathways.
  • Utilizing conditional knockout mice to assess tumor development after SIVA ablation.

Main Results:

  • SIVA is overexpressed in KRAS-mutated NSCLC cells independently of p53 status.
  • SIVA overexpression stimulates tumor growth by activating mTOR signaling.
  • Ablation of SIVA in mice significantly inhibits tumor development.
  • These findings highlight SIVA's critical role in NSCLC tumorigenesis.

Conclusions:

  • SIVA acts as an oncogene in KRAS-mutated NSCLC by promoting tumorigenesis via mTOR signaling.
  • SIVA represents a promising novel therapeutic target for NSCLC, a cancer with unmet clinical needs.
  • Targeting SIVA may offer a new strategy for treating patients with this challenging disease.

More Related Videos

Rendering SiO2/Si Surfaces Omniphobic by Carving Gas-Entrapping Microtextures Comprising Reentrant and Doubly Reentrant Cavities or Pillars08:02

Rendering SiO2/Si Surfaces Omniphobic by Carving Gas-Entrapping Microtextures Comprising Reentrant and Doubly Reentrant Cavities or Pillars

Published on: February 11, 2020

9.5K
Reverse Dissection and DiceCT Reveal Otherwise Hidden Data in the Evolution of the Primate Face08:15

Reverse Dissection and DiceCT Reveal Otherwise Hidden Data in the Evolution of the Primate Face

Published on: January 7, 2019

7.4K

Related Concept Videos

Understanding the Self01:28

Understanding the Self

The self is a central aspect of human identity, encompassing an individual’s beliefs, emotions, perceptions, and experiences. It is a cognitive and psychological construct that enables individuals to interpret their traits and behaviors, influencing how they perceive themselves and interact with the world. While personality consists of stable and enduring characteristics, the self is shaped by self-perception and social experiences. This distinction highlights the dynamic nature of the...
433
Sutures of the Skull01:22

Sutures of the Skull

The human skull is composed of several bones that come together to protect the brain and support the structures of the face. The junctions where these bones meet are called sutures.
Sutures are immobile joints between adjacent bones of the skull. The narrow gap between the bones is filled with dense, fibrous connective tissue that unites the bones. The long sutures located between the skull bones are not straight but instead follow irregular, tightly twisting paths. These twisting lines tightly...
14.6K
Symmetry01:26

Symmetry

The equation of an ellipse centered at the origin defines all points whose distances from the center maintain a constant ratio between the horizontal and vertical axes. This equation results in a smooth, closed curve that extends further along the x-axis than the y-axis, giving it a horizontal orientation. Such an ellipse demonstrates three kinds of symmetry: across the x-axis, across the y-axis, and about the origin. These symmetries are essential in understanding the graph's structure and...
385
Personal Identity01:25

Personal Identity

Personal identity is the deeply felt sense of self that individuals cultivate over time, intricately woven from intrinsic qualities they consider essential to their existence—qualities such as morality, intelligence, and friendliness. These attributes serve as vital internal benchmarks, guiding individuals in evaluating whether their actions resonate with their true selves.When personal identity takes center stage in one's life, individuals often emphasize their distinctiveness,...
620
Parallel-axis Theorem01:06

Parallel-axis Theorem

The parallel-axis theorem provides a convenient and quick method of finding the moment of inertia of an object about an axis parallel to the axis passing through its center of mass. Consider a thin rod as an example. There is a striking similarity between the process of finding the moment of inertia of a thin rod about an axis through its middle, where the center of mass lies, and about an axis through its end using the conventional method. In the conventional method, the concept of linear mass...
8.6K
Altered States of Awareness01:06

Altered States of Awareness

Altered states of consciousness represent significant deviations from one's normal mental state. These deviations can range from subtle changes in awareness to profound transformations in perception, thought processes, and sensory experiences. Altered states of consciousness can be triggered by various factors, including drug use, meditation, hypnosis, illness, or even intense fatigue.
The ingestion of substances like stimulants or hallucinogens leads to chemical alterations in the brain...
1.5K