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Related Experiment Video

Updated: Apr 11, 2026

Creating Virtual-hand and Virtual-face Illusions to Investigate Self-representation

Creating Virtual-hand and Virtual-face Illusions to Investigate Self-representation

Published on: March 1, 2017

Two Faces of SIVA.

Lois Resnick-Silverman¹, James J Manfredi²

¹Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York.

Cancer Discovery

|June 4, 2015

Summary

In non-small cell lung cancer, the gene SIVA promotes tumor growth by activating mTOR signaling. Inhibiting SIVA in mice stopped tumor development, suggesting SIVA as a potential therapeutic target for lung cancer.

Area of Science:

Oncology
Molecular Biology
Cancer Genetics

Background:

Non-small cell lung cancer (NSCLC) with KRAS mutations presents limited therapeutic options.
The p53 tumor suppressor pathway plays a critical role in apoptosis and cancer progression.
SIVA is a known p53 target gene involved in regulating apoptosis.

Purpose of the Study:

To investigate the role of SIVA in KRAS-mutated NSCLC.
To determine the mechanism by which SIVA promotes tumorigenesis.
To evaluate SIVA as a potential therapeutic target for NSCLC.

Main Methods:

Analysis of SIVA expression in NSCLC cell lines with mutated KRAS.
Investigating the p53-independent regulation of SIVA.
Studying the impact of SIVA on mTOR signaling pathways.

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Utilizing conditional knockout mice to assess tumor development after SIVA ablation.

Main Results:

SIVA is overexpressed in KRAS-mutated NSCLC cells independently of p53 status.
SIVA overexpression stimulates tumor growth by activating mTOR signaling.
Ablation of SIVA in mice significantly inhibits tumor development.
These findings highlight SIVA's critical role in NSCLC tumorigenesis.

Conclusions:

SIVA acts as an oncogene in KRAS-mutated NSCLC by promoting tumorigenesis via mTOR signaling.
SIVA represents a promising novel therapeutic target for NSCLC, a cancer with unmet clinical needs.
Targeting SIVA may offer a new strategy for treating patients with this challenging disease.