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Updated: Apr 11, 2026

Induction and Analysis of Epithelial to Mesenchymal Transition
Published on: August 27, 2013
[Research progress on epithelial-mesenchymal transition in cancer recurrence and metastasis]
Zhi-xian Liu1, Er-qing Wei1, Yun-bi Lu1
1Department of Pharmacology, Zhejiang University, School of Medicine, Hangzhou 310058, China;
Abstract:
Epithelial-mesenchymal transition (EMT) is a process in which epithelial cells lose their morphology and function and gradually transformed into mesenchymal-like cells. It is considered that EMT is the main cause for tumor recurrence and metastasis. Many factors are involved in the regulation of EMT, such as E-cadherin, transforming growth factor-β, Wnt signaling pathway, microRNA and EMT-related transcription factors. This article reviews the research progress on EMT and the involved mechanisms, and thus to provide a new perspective on cancer therapy in the future.
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