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Related Concept Videos

Adrenal Gland Disorders01:27

Adrenal Gland Disorders

4.1K
Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
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Anatomy of the Adrenal Glands01:17

Anatomy of the Adrenal Glands

6.3K
The adrenal or supra-renal glands, situated above the kidneys and aligned with the twelfth rib, are paired pyramid-shaped structures crucial for the body's stress response. During stress, these glands secrete hormones vital for adaptive physiological reactions.
These glands possess a distinctive yellow tinge due to the stored cholesterol and fatty acids required for hormone synthesis. They are encased in a fibrous capsule and cushioned by fat.
The adrenal gland comprises two distinct...
6.3K
Hormones of the Adrenal Glands01:31

Hormones of the Adrenal Glands

6.9K
Adrenal hormones play a pivotal role in maintaining the body's electrolyte balance and orchestrating responses to stress, showcasing the intricate functions of the adrenal cortex and medulla.
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and...
6.9K
Adrenergic Receptors (Adrenoceptors): Classification01:27

Adrenergic Receptors (Adrenoceptors): Classification

5.7K
Adrenergic receptors, or adrenoceptors, respond to the autonomic neurotransmitter noradrenaline and other endogenous catecholamine agonists. They are classified into two main families, α and β, based on their pharmacological response and are further subdivided depending on their location, elicited response, and affinity to specific agonists or antagonists.
α-Adrenoceptors
α-Adrenoceptors are classified into two main subtypes: α1 and α2. The α1 adrenoceptors,...
5.7K
Adrenergic Receptors: β Subtype01:26

Adrenergic Receptors: β Subtype

4.6K
β-adrenoceptors have varied sensitivities towards adrenaline, noradrenaline, and isoprenaline. The order of agonist potency is as follows:
Isoprenaline > Adrenaline > Noradrenaline
Neurotransmitter binding to these receptors causes activation of adenylyl cyclase resulting in increased concentrations of cAMP and modulation of calcium ion channels within the cell. They are further classified into β1, β2, and β3 subtypes.
β1-adrenoceptors: β1-adrenoceptors...
4.6K
Sympathetic Pathways: Collateral Ganglia and Adrenal Medulla01:27

Sympathetic Pathways: Collateral Ganglia and Adrenal Medulla

3.4K
The sympathetic pathways of the collateral ganglia and adrenal medulla serve unique but interconnected roles in the sympathetic response.
Collateral Ganglia
Sympathetic preganglionic axons reach the collateral ganglia along the route of splanchnic nerves. These nerves bypass the sympathetic trunk and communicate with sympathetic postganglionic neurons housed in the prevertebral ganglia. These ganglia supply the organs of the abdominopelvic cavity.
The greater splanchnic nerve, formed by the...
3.4K

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Related Experiment Video

Updated: Apr 11, 2026

A Novel Method: Super-selective Adrenal Venous Sampling
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A Novel Method: Super-selective Adrenal Venous Sampling

Published on: September 15, 2017

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Adrenocortical carcinoma.

Eric Baudin1,

  • 1Département de Médecine, Gustave Roussy, 114, rue Édouard-Vaillant, Paris South University, Villejuif Cedex 94805, France; Département de Nucléaire et de Cancérologie Endocrinienne, Gustave Roussy, 114, rue Édouard-Vaillant, Paris South University, Villejuif Cedex 94805, France; Faculté de Médecine, INSERM UMR 1185, 63 rue Gabriel Péri, F-94276 Le Kremlin-Bicêtre, Université Paris Sud, Paris, France.

Endocrinology and Metabolism Clinics of North America
|June 4, 2015
PubMed
Summary

Recent advancements in adrenocortical carcinoma (ACC) treatment involve better risk assessment and molecular profiling. These developments pave the way for improved patient outcomes and novel therapeutic strategies in cancer care.

Keywords:
Adrenocortical carcinomaChemotherapyMetastasisMitotanePredictorsPrognosisSurrogateSurvival

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Area of Science:

  • Oncology
  • Genomics
  • Molecular Biology

Background:

  • Adrenocortical carcinoma (ACC) treatment has seen limited progress, necessitating novel therapeutic strategies.
  • Understanding the molecular underpinnings of ACC is crucial for developing targeted therapies.

Purpose of the Study:

  • To summarize recent developments in adrenocortical carcinoma (ACC) treatment.
  • To highlight advances in diagnostic, prognostic, and therapeutic approaches for ACC.

Main Methods:

  • Review of recent literature on adrenocortical carcinoma (ACC) treatment.
  • Analysis of integrated epigenomic and genomic data for emerging therapeutic targets.
  • Standardization of proliferative index analyses and clinical characterization of ACC patients.

Main Results:

  • Development of diagnostic and prognostic risk stratification algorithms for ACC.
  • Evidence supporting the impact of historical therapies on overall survival in ACC.
  • Identification of emerging therapeutic targets through integrated molecular analyses.

Conclusions:

  • Comprehensive clinical and molecular characterization of ACC patients is essential.
  • Standardized assessments and referral to specialized cancer centers improve ACC management.
  • Networking and molecular insights form the foundation for future ACC therapeutic breakthroughs.