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Related Experiment Video

Updated: Apr 11, 2026

Microelectrode Guided Implantation of Electrodes into the Subthalamic Nucleus of Rats for Long-term Deep Brain Stimulation
10:52

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Internal Pulse Generators in Deep Brain Stimulation: Rechargeable or Not?

Michele Rizzi1, Giuseppe Messina1, Federica Penner1

  • 1Department of Neurosurgery, IRCCS Fondazione Istituto Neurologico Carlo Besta, Milan, Italy.

World Neurosurgery
|June 4, 2015
PubMed
Summary

Rechargeable internal pulse generators (IPGs) for deep brain stimulation (DBS) offer significant long-term cost savings compared to non-rechargeable IPGs. This economic advantage is projected across various patient groups, including those with Parkinson disease and dystonia.

Keywords:
Cost-effective analysisDeep brain stimulationHardware-related complicationsInternal pulse generatorRechargeable battery

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Area of Science:

  • Neurology
  • Health Economics
  • Biomedical Engineering

Background:

  • Deep brain stimulation (DBS) is a key therapy for neurologic disorders, but high internal pulse generator (IPG) costs pose a challenge.
  • Rechargeable IPGs are emerging as an alternative to traditional non-rechargeable devices.

Purpose of the Study:

  • To compare the implantation costs of rechargeable versus non-rechargeable IPGs in DBS procedures.
  • To assess the potential economic benefits for the healthcare system.

Main Methods:

  • Analysis of 149 patients undergoing IPG replacement surgery.
  • Hypothetical implantation of rechargeable IPGs versus non-rechargeable IPGs.
  • Cost estimation over patient life expectancy and cost-effectiveness analysis.

Main Results:

  • A projected savings of €5,918,188 over a 47-year life expectancy was calculated.
  • Significant cost reductions were observed, including management of complications.
  • Savings are expected in dystonic patients, Parkinson disease patients, and other DBS patient categories.

Conclusions:

  • Rechargeable IPGs offer clinical advantages over non-rechargeable devices.
  • Widespread adoption of rechargeable IPGs for DBS can yield substantial economic savings for healthcare systems.