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Family History in Young Patients With Stroke
Vincent Thijs1, Ulrike Grittner2, Martin Dichgans2
1From the Department of Neurosciences, Experimental Neurology, KU Leuven, University of Leuven, Leuven, Belgium (V.T.); Department of Neurology, VIB-Vesalius Research Center, University Hospitals Leuven, Leuven, Belgium (V.T.); Center for Stroke Research (U.G.) and Department for Biostatistics and Clinical Epidemiology (U.G.), Charité-University Medical Centre Berlin, Berlin, Germany; Institute for Stroke and Dementia Research, Klinikum der Universität München, Munich, Germany (M.D.); The German Center for Neurodegenerative Diseases (DZNE, Munich), Munich, Germany (M.D.); Munich Cluster for Systems Neurology (SyNergy), Munich, Germany (M.D.); Department of Neurology, Medical University of Graz, Graz, Austria (C.E., F.F., R.S.); Albrecht-Kossel-Institute for Neuroregeneration (AKos), Centre for Mental Health Disease (A.-K.G., A.R.) and Institute of Medical Psychology and Medical Sociology Medical Faculty (P.K.), University of Rostock, Rostock, Germany; Department of Neurology, University Medicine Greifswald, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany (C.K., B.v.S.); Department of Neurology, New York University School of Medicine (E.K.); Institut für Klinische Epidemiologie und Angewandte Biometrie (IKEaB), Tübingen, Germany (P.M.); Department of Clinical Sciences Neurology, Lund University, Lund, Sweden (B.N.); Wilhelms University of Muenster, Muenster, Germany (E.B.R.); Stroke Prevention Research Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom (P.M.R.); Department of Neurology, Justus Liebig University Giessen, Giessen, Germany (C.T.); and Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (T.T.). vincent.thijs@uzleuven.be.
A family history of stroke is common in young patients but not linked to specific stroke subtypes. However, young women with stroke are more likely to have a maternal history of stroke.
Area of Science:
- Neurology
- Genetics
- Epidemiology
Background:
- Family history of stroke is a known risk factor.
- Investigating its role in young stroke patients is crucial.
Purpose of the Study:
- To determine if family history of stroke predisposes to specific stroke subtypes.
- To examine sex differences in family history of stroke among young stroke patients.
Main Methods:
- Utilized data from the prospective Stroke in Fabry Patients study.
- Included young patients (<55 years) with transient ischemic attack and ischemic stroke.
- Collected data on cardiovascular risk factors, family history, and detailed stroke subtyping.
Main Results:
- 37.3% of patients had a family history of stroke.
- Female patients more frequently reported maternal lineage stroke history.
- No association found between family history and stroke subtype or white matter disease.
- Patients with dissection less frequently reported family history of stroke.
Conclusions:
- Family history of stroke is not specifically related to pathogenic stroke subtypes in young patients.
- Young women with stroke more often report stroke in their maternal lineage.
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