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Related Concept Videos

Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

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Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
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Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
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Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

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Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
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Attention-Deficit/Hyperactivity Disorder01:30

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Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
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Schizophrenia01:17

Schizophrenia

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Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
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Negative and Cognitive Symptoms of Schizophrenia01:30

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Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
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Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia
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Childhood neglect predicts disorganization in schizophrenia through grey matter decrease in dorsolateral prefrontal

A Cancel1,2, M Comte1, R Truillet3

  • 1Timone Institute of Neuroscience, UMR 7289, CNRS and Aix-Marseille University, Marseille, France.

Acta Psychiatrica Scandinavica
|June 4, 2015
PubMed
Summary
This summary is machine-generated.

Childhood emotional neglect is linked to reduced grey matter in the right dorsolateral prefrontal cortex (DLPFC) in schizophrenia patients. This brain change may contribute to disorganization symptoms in schizophrenia.

Keywords:
childhood traumadisorganizationdorsolateral prefrontal cortexschizophreniavoxel-based morphometry

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Brain Imaging

Background:

  • Childhood psychosocial trauma is a known risk factor for schizophrenia.
  • Brain alterations, including grey matter reduction, are observed in schizophrenia.
  • The specific impact of childhood trauma on brain morphology in schizophrenia requires further investigation.

Purpose of the Study:

  • To investigate the relationship between childhood trauma, brain morphology, and schizophrenia symptoms.
  • To explore how childhood trauma influences brain structure in individuals with schizophrenia.

Main Methods:

  • Utilized optimized voxel-based morphometry (VBM) on MRI scans from 21 schizophrenia patients and 30 healthy controls.
  • Assessed childhood trauma using the Childhood Trauma Questionnaire.
  • Rated schizophrenia symptoms using the Scale for the Assessment of Negative Symptoms (SANS) and Scale for the Assessment of Positive Symptoms (SAPS).
  • Employed structural equation modeling for path analysis in the schizophrenia group.

Main Results:

  • A negative association was found between total grey matter volume and emotional neglect (EN) in schizophrenia patients.
  • VBM analysis revealed an inverse association between EN and grey matter density in the right dorsolateral prefrontal cortex (DLPFC).
  • Path analysis indicated that EN predicted DLPFC grey matter density, which subsequently predicted symptom disorganization.

Conclusions:

  • Childhood emotional neglect may impact schizophrenia psychopathology.
  • Developmental effects on brain regions like the DLPFC, influenced by EN, could mediate this impact.