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[Endocrine abnormalities in patients with chronic renal failure - part I]

Robert Krysiak1, Agnieszka Kędzia1, Joanna Krupej-Kędzierska1

  • 1Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland.

Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego
|June 4, 2015
PubMed

Insights

Chronic kidney disease impairs hormone regulation, leading to significant endocrine issues like hyperparathyroidism and thyroid dysfunction. This review explores these changes, offering insights into diagnosis and potential treatments for kidney failure patients.

Area of Science:

  • Endocrinology
  • Nephrology
  • Metabolic disorders

Context:

  • Chronic kidney disease (CKD) significantly impacts hormonal balance.
  • Later stages of CKD exhibit impaired adaptive hormonal responses.
  • Endocrine disturbances are a hallmark of advanced renal failure.

Purpose:

  • To review key endocrine alterations in chronic renal failure.
  • To discuss recent developments in parathyroid, thyroid, and growth hormone axes.
  • To provide insights into diagnosis and therapeutic strategies for endocrine complications in CKD.

Summary:

  • CKD disrupts hormone synthesis, metabolism, and elimination.
  • Characteristic endocrine complications include secondary/tertiary hyperparathyroidism, hypothalamic-pituitary-thyroid axis dysfunction, and impaired growth.
  • Pathogenesis is complex and multifactorial, involving intricate hormonal regulatory pathways.

Impact:

  • Highlights the clinical relevance of endocrine changes in CKD.
  • Facilitates understanding of complex hormonal dysregulation in renal failure.
  • Informs diagnostic approaches and therapeutic interventions for endocrine disorders in CKD patients.
Keywords:
chronic renal diseasegrowth hormone-insulin-like growth factor 1 axisparathyroid glandsthyroid

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