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Related Experiment Video

Updated: Apr 11, 2026

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Association study between C-reactive protein polymorphisms and ischaemic stroke.

Jichen Du, Dan Yu, Xiaofeng Li

    Neurological Research
    |June 4, 2015
    PubMed
    Summary
    This summary is machine-generated.

    This study investigated the association between two C-reactive protein (CRP) gene single nucleotide polymorphisms (SNPs) and ischaemic stroke risk in the Chinese Han population. No significant association was found between these CRP SNPs and ischaemic stroke.

    Keywords:
    C-reactive protein,Gene polymorphisms,Haplotype,Ischaemic stroke,rs1130864,rs3093059

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    Area of Science:

    • Genetics
    • Cardiovascular Disease Epidemiology
    • Biomarkers

    Background:

    • C-reactive protein (CRP) is an inflammation marker linked to cardiovascular disease and ischaemic stroke.
    • Specific single nucleotide polymorphisms (SNPs) in the CRP gene may influence CRP levels, but their association with ischaemic stroke is debated.
    • Investigating CRP gene variants in diverse populations is crucial for understanding stroke risk factors.

    Purpose of the Study:

    • To examine the association between two CRP gene SNPs (rs1130864 and rs3093059) and ischaemic stroke risk.
    • To evaluate the relationship between CRP haplotypes and ischaemic stroke in the Chinese Han population.
    • To clarify the role of specific CRP genetic variations in ischaemic stroke etiology.

    Main Methods:

    • A case-control study involving 158 ischaemic stroke patients and 290 controls from the Chinese Han population.
    • Genotyping of CRP SNPs rs1130864 and rs3093059 using PCR-restriction fragment length polymorphism (PCR-RFLP).
    • Haplotype analysis and association testing with permutation tests, adjusting for traditional risk factors.

    Main Results:

    • The CRP SNPs rs1130864 and rs3093059 were in Hardy-Weinberg equilibrium in controls.
    • No statistically significant differences in genotype distributions were observed between ischaemic stroke patients and controls.
    • Three major haplotypes (C-T, T-T, C-C) derived from the linked SNPs showed no association with ischaemic stroke or its subtypes.

    Conclusions:

    • The CRP gene SNPs rs1130864 and rs3093059 are not associated with ischaemic stroke in the studied Chinese Han population.
    • These specific CRP genetic variations do not appear to be significant risk factors for ischaemic stroke in this demographic.
    • Further research may be needed to explore other genetic or environmental factors influencing ischaemic stroke risk.