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Endogenous cholecystokinin does not decrease food intake or gastric emptying in fasted rats.

G P Smith1, D Greenberg, J D Falasco

  • 1Department of Psychiatry, Cornell University Medical College, White Plains, New York 10605.

The American Journal of Physiology
|December 1, 1989
PubMed
Summary
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Endogenous cholecystokinin (CCK) from the small intestine does not suppress food intake or gastric emptying in rats. Exogenous CCK, however, did show these inhibitory effects, suggesting a complex regulatory role.

Area of Science:

  • Gastroenterology
  • Endocrinology
  • Physiology

Background:

  • Cholecystokinin (CCK) is a gut hormone implicated in regulating appetite and gastric motility.
  • The role of endogenously released CCK in physiological control of food intake and gastric emptying remains debated.

Purpose of the Study:

  • To investigate the inhibitory effect of CCK released from the small intestine on food intake and gastric emptying.
  • To compare the effects of endogenous CCK stimulation with exogenous CCK administration.

Main Methods:

  • Male rats were deprived of food for 17 hours.
  • Soybean trypsin inhibitor (STI) was infused intragastrically or intraduodenally to stimulate endogenous CCK release.
  • Food intake and gastric emptying were measured.
  • Plasma CCK levels were quantified via bioassay.

Related Experiment Videos

  • Exogenous CCK-8 was administered intraperitoneally for comparison.

    • Main Results:

    • Intraduodenal or intragastric STI infusions significantly increased plasma CCK levels (6-9 fold) but did not affect food intake or gastric emptying.
    • Exogenous CCK-8 administration significantly inhibited both food intake and gastric emptying.
    • Exogenous CCK-8 produced smaller increases in plasma CCK compared to STI.

    Conclusions:

    • Endogenous CCK release stimulated by STI in the small intestine does not appear to inhibit food intake or gastric emptying in food-deprived rats.
    • These findings challenge the hypothesis that CCK's physiological role involves inhibiting food intake and gastric emptying.
    • Differential effects of exogenous versus endogenous CCK warrant further investigation into CCK's complex regulatory mechanisms.