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Pulmonary Hypertension: Classification and Pathogenesis01:30

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Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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[Lung involvement in systemic sclerosis].

M Posa, M Stelle, F Lador

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    Summary
    This summary is machine-generated.

    Systemic sclerosis (SSc) lung disease, including interstitial lung disease (ILD) and pulmonary arterial hypertension (PAH), is a leading cause of mortality. Current treatments offer limited benefit, highlighting an unmet need for improved therapies for SSc-ILD and PAH.

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    Area of Science:

    • Rheumatology and Pulmonology
    • Cardiovascular Medicine

    Context:

    • Systemic sclerosis (SSc) is a complex autoimmune disease.
    • Lung involvement, specifically interstitial lung disease (ILD) and pulmonary arterial hypertension (PAH), significantly impacts SSc patient prognosis and mortality.
    • ILD and PAH often coexist and are the primary drivers of death in SSc patients.

    Purpose:

    • To highlight the critical impact of lung manifestations in Systemic Sclerosis.
    • To underscore the limitations of current therapeutic strategies for SSc-associated ILD and PAH.
    • To emphasize the urgent need for novel and more effective treatment options.

    Summary:

    • Systemic sclerosis (SSc) is characterized by diverse organ involvement, with lung complications being paramount.
    • Interstitial lung disease (ILD) can progress to respiratory failure, while pulmonary arterial hypertension (PAH) may lead to right heart failure.
    • Despite existing treatments, both SSc-ILD and PAH represent significant unmet medical needs.

    Impact:

    • Identifies SSc-ILD and PAH as major contributors to mortality and reduced quality of life in Systemic Sclerosis.
    • Emphasizes the critical need for advancements in therapeutic strategies for these debilitating conditions.
    • Provides a concise overview for researchers and clinicians focusing on SSc-related cardiopulmonary complications.