Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammation01:38

Inflammation

65.2K
Overview
65.2K
Obesity01:24

Obesity

1.6K
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.6K
Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

7.0K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
7.0K
Inflammatory Response01:28

Inflammatory Response

19.6K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
19.6K
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

2.0K
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
2.0K
Lipid-derived Compounds in the Human Body01:31

Lipid-derived Compounds in the Human Body

7.5K
Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various  biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
7.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association between light exposure patterns and multidimensional health outcomes in individuals with myalgic encephalomyelitis/chronic fatigue syndrome: findings from an observational cross-sectional cohort study.

Journal of translational medicine·2026
Same author

[Agentic artificial intelligence in nutrition: from isolated screening tools to autonomous nutritional support systems].

Nutricion hospitalaria·2026
Same author

Preservation of muscle mass assessed by ultrasound during a meal replacement-based hypocaloric intervention in obese individuals: a real-world clinical trial.

Nutricion hospitalaria·2026
Same author

Integrating patient-reported weight gain cause narratives into personalized obesity management: a data-driven approach with natural language processing and machine learning.

Frontiers in nutrition·2026
Same author

Design and rationale of the EFFORTII project: a multicentric randomised-controlled trial on the impact of continued nutritional therapy at hospital discharge.

BMJ open·2026
Same author

Influence of oncostatin M and leukemia inhibitor factor on sarcopenia in individuals with cancer and malnutrition.

Endocrinologia, diabetes y nutricion·2026

Related Experiment Video

Updated: Apr 11, 2026

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
07:46

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation

Published on: April 3, 2017

26.1K

[Inflammation and obesity (lipoinflammation)].

Olatz Izaola1, Daniel de Luis1, Ignacio Sajoux2

  • 1Centro de Investigación de Endocrinología y Nutrición Clínica. Servicio de Endocrinología y Nutrición. Hospital Clínico Universitario de Valladolid. Universidad de Valladolid (Valladolid), España.. olatzizaola@yahoo.es.

Nutricion Hospitalaria
|June 5, 2015
PubMed
Summary

Obesity involves chronic inflammation and adipose tissue remodeling. Pro-resolving mediators show promise as therapeutic targets for managing this complex disease and its complications.

More Related Videos

Isolation of Adipose Tissue Immune Cells
07:09

Isolation of Adipose Tissue Immune Cells

Published on: May 22, 2013

37.3K
Characterization of Immune Cells in Human Adipose Tissue by Using Flow Cytometry
07:32

Characterization of Immune Cells in Human Adipose Tissue by Using Flow Cytometry

Published on: March 6, 2018

18.6K

Related Experiment Videos

Last Updated: Apr 11, 2026

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
07:46

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation

Published on: April 3, 2017

26.1K
Isolation of Adipose Tissue Immune Cells
07:09

Isolation of Adipose Tissue Immune Cells

Published on: May 22, 2013

37.3K
Characterization of Immune Cells in Human Adipose Tissue by Using Flow Cytometry
07:32

Characterization of Immune Cells in Human Adipose Tissue by Using Flow Cytometry

Published on: March 6, 2018

18.6K

Area of Science:

  • Metabolic Disorders
  • Immunology
  • Cell Biology

Background:

  • Obesity is a chronic, global disease with severe health implications and high costs.
  • Chronic low-grade inflammation (lipoinflammation) is a key characteristic perpetuating obesity and its complications.
  • Adipose tissue remodeling is central to lipoinflammation, involving multiple regulatory factors.

Purpose of the Study:

  • To review mechanisms regulating adipose tissue remodeling and lipoinflammation in obesity.
  • To explore the role of pro-resolving mediators in obesity and inflammation resolution.
  • To identify potential therapeutic targets for obesity treatment.

Main Methods:

  • Literature review of recent evidence on adipose tissue regulation.
  • Analysis of studies on lipoinflammation mechanisms in obesity.
  • Examination of research on pro-resolving mediators in inflammatory processes.

Main Results:

  • Adipose tissue undergoes significant remodeling in obesity, contributing to chronic inflammation.
  • Pro-resolving mediators are identified as crucial in regulating inflammatory processes.
  • These mediators present potential therapeutic avenues for obesity management.

Conclusions:

  • Understanding adipose tissue remodeling and lipoinflammation is key to combating obesity.
  • Pro-resolving mediators offer a novel therapeutic strategy for obesity and related inflammatory conditions.
  • A multidisciplinary approach is essential for addressing the complexities of obesity.