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Elastofibroma dorsi: a case report with an immunohistochemical and ultrastructural studies
Natsuko Kakudo1, Naoki Morimoto2, Takeshi Ogawa2
1Department of Plastic and Reconstructive Surgery, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, Osaka, 573-1010, Japan. kakudon@hirakata.kmu.ac.jp.
Medical Molecular Morphology
|June 5, 2015
Summary
Elastofibroma dorsi is a benign tumor characterized by abnormal elastic fiber proliferation. This study suggests elastin deposition on collagen fibers contributes to its formation.
Area of Science:
- Pathology
- Dermatology
- Oncology
Background:
- Elastofibroma is a rare, benign fibrous tumor.
- It typically arises in the subscapular region.
Observation:
- A case of elastofibroma dorsi in a 77-year-old woman was studied.
- Histochemical, immunohistochemical, and ultrastructural analyses were performed.
Findings:
- Tumor cells contained collagen and abundant elastic fibers.
- Fibroblasts showed positivity for CD34, vimentin, and α-smooth muscle actin.
- Elastin deposition on collagen fibers was observed, suggesting a role in abnormal elastic fiber formation.
Implications:
- Understanding the pathogenesis of elastofibroma is crucial for diagnosis.
- This study provides insights into the cellular and extracellular matrix changes in elastofibroma.
