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Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Adult Stem Cells01:33

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Clinical Applications of Epidermal Stem Cells01:19

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Stem Cell Niche01:26

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The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
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Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

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A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
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Related Experiment Video

Updated: Apr 11, 2026

Mammosphere Formation Assay from Human Breast Cancer Tissues and Cell Lines
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Mammary Stem Cells: A Clinician's View.

José Schneider1

  • 1Facultad de Ciencias de la Salud, Universidad Rey Juan Carlos, Avenida de Atenas, Alcorcón, Madrid, 28922, Spain, jose.schneider@urjc.es.

Methods in Molecular Biology (Clifton, N.J.)
|June 5, 2015
PubMed
Summary

Mammary stem cells have been studied for over a decade, revealing much about their properties. However, a significant gap remains in translating this knowledge into effective clinical applications for breast cancer.

Area of Science:

  • * Oncology
  • * Stem Cell Biology
  • * Translational Medicine

Background:

  • * Mammary stem cells (MSCs) were identified and isolated over 10 years ago.
  • * Significant research has elucidated their fundamental properties and behavior patterns.

Observation:

  • * Despite extensive research, a notable disparity exists between current scientific understanding of MSCs and their practical clinical utility.
  • * This chapter offers a critical clinical perspective on the challenges and opportunities in mammary stem cell research.

Findings:

  • * The chapter critically reviews the existing body of knowledge on mammary stem cells from a clinical standpoint.
  • * It highlights the translational gap between basic science discoveries and clinical implementation.

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Isolation and Functional Assessment of Human Breast Cancer Stem Cells from Cell and Tissue Samples
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Last Updated: Apr 11, 2026

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Implications:

  • * Addressing the identified gap is crucial for advancing breast cancer treatment and patient outcomes.
  • * Further research and collaboration are needed to bridge basic science findings with clinical applications of mammary stem cells.