Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Distribution Reliability and Automation01:25

Distribution Reliability and Automation

644
Distribution reliability in electrical power systems is critical for ensuring an uninterrupted power supply to consumers at minimal cost. According to IEEE Standard Terms, reliability is the probability that a device will function without failure over a specified time period or amount of usage. For electric power distribution, this translates to maintaining continuous power supply and addressing customer concerns over power outages. Several indices, as defined by IEEE Standard 1366-2012, are...
644
Quality Assurance01:19

Quality Assurance

3.9K
Quality assurance is the overarching term used to describe the activities employed to ensure the proper performance of a system. These activities can be classified into three categories: quality control, quality assessment, and internal corrective measures. Typically, these activities work cyclically: quality control is performed before and during the analysis, while quality assessment occurs during and after the investigation. Internal corrective measures are implemented based on the findings...
3.9K
Global Regulatory Systems01:28

Global Regulatory Systems

922
Global regulatory systems in bacteria enable rapid and coordinated responses to environmental changes by integrating sensory inputs with gene expression, ensuring efficient adaptation to fluctuating conditions. Key global regulatory mechanisms include regulons, two-component systems, sigma factors, and secondary messengers.Regulons and Global RegulatorsA regulon is a collection of genes and operons controlled by a common global regulator. These regulators enable bacteria to prioritize resource...
922
Integration of Synaptic Events01:28

Integration of Synaptic Events

6.4K
Synaptic integration mainly includes the summation of graded potentials. Graded potentials, regardless of their type, cause subtle alterations in membrane voltage, resulting in either depolarization or hyperpolarization. These incremental changes, when combined or summed, can propel the neuron toward its threshold. Consider, for example, a membrane experiencing a +15 mV shift, causing it to depolarize from -70 mV to -55 mV. In this scenario, graded potentials govern the membrane's ability to...
6.4K
Modified-Release Drug Delivery Systems: Overview01:19

Modified-Release Drug Delivery Systems: Overview

192
Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...
192
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

287
Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
287

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Implementing informed consent in federated medical research: a blueprint designed to safeguard data subject rights in Germany.

Journal of translational medicine·2026
Same author

Concept and feasibility of privacy-preserving record linkage of cancer registry data and claims data in Germany: results from the DigiNet study on stage IV non-small cell lung cancer.

Journal of cancer research and clinical oncology·2025
Same author

[Improving record linkage for health research-how to overcome deficiencies?]

Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·2025
Same author

Efficacy and cost-effectiveness of extended nursing roles in dementia care: Results of the cluster-randomized trial InDePendent.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

The benefits of fully electronic consent management and consent collection via a tablet PC in supporting time-critical pandemic research-an example from a NAPKON COVID-19 project.

Frontiers in digital health·2025
Same author

Consent Management 2.0: Empowering Patient Will in Medical Research and Care.

Studies in health technology and informatics·2025

Related Experiment Video

Updated: Apr 11, 2026

Automated Robotic Liquid Handling Assembly of Modular DNA Devices
11:22

Automated Robotic Liquid Handling Assembly of Modular DNA Devices

Published on: December 1, 2017

13.0K

A workflow-driven approach to integrate generic software modules in a Trusted Third Party.

Martin Bialke1, Peter Penndorf2,3, Tim Wegner4

  • 1Institute for Community Medicine, Section Epidemiology of Health Care and Community Health, University Medicine Greifswald, Ellernholzstr. 1-2, 17487, Greifswald, Germany. martin.bialke@uni-greifswald.de.

Journal of Translational Medicine
|June 5, 2015
PubMed
Summary
This summary is machine-generated.

Implementing a Trusted Third Party Dispatcher streamlines data protection for cohort studies. This workflow-management system ensures security and ethical compliance, reducing implementation and maintenance efforts for research projects.

More Related Videos

An Open Source Technology Platform to Manufacture Hydrogel-Based 3D Culture Models in an Automated and Standardized Fashion
08:29

An Open Source Technology Platform to Manufacture Hydrogel-Based 3D Culture Models in an Automated and Standardized Fashion

Published on: March 31, 2022

5.0K
The Modular Design and Production of an Intelligent Robot Based on a Closed-Loop Control Strategy
11:53

The Modular Design and Production of an Intelligent Robot Based on a Closed-Loop Control Strategy

Published on: October 14, 2017

12.4K

Related Experiment Videos

Last Updated: Apr 11, 2026

Automated Robotic Liquid Handling Assembly of Modular DNA Devices
11:22

Automated Robotic Liquid Handling Assembly of Modular DNA Devices

Published on: December 1, 2017

13.0K
An Open Source Technology Platform to Manufacture Hydrogel-Based 3D Culture Models in an Automated and Standardized Fashion
08:29

An Open Source Technology Platform to Manufacture Hydrogel-Based 3D Culture Models in an Automated and Standardized Fashion

Published on: March 31, 2022

5.0K
The Modular Design and Production of an Intelligent Robot Based on a Closed-Loop Control Strategy
11:53

The Modular Design and Production of an Intelligent Robot Based on a Closed-Loop Control Strategy

Published on: October 14, 2017

12.4K

Area of Science:

  • Health Informatics
  • Data Security
  • Medical Research Ethics

Background:

  • Cohort studies and registries handle vast personal medical data, increasing the importance of data protection and information security.
  • Ethical considerations and legal obligations necessitate robust technical and organizational measures for data management.
  • A Trusted Third Party (TTP) is crucial for ensuring compliance and security in research data handling.

Purpose of the Study:

  • To define and organize a consistent workflow-management system for establishing a Trusted Third Party.
  • To detail the technical implementation of a TTP Dispatcher with core functionalities like identity management, pseudonym administration, and informed consent management.
  • To present a flexible and extensible technical concept that addresses legal and ethical requirements for diverse research scenarios.

Main Methods:

  • Development of a workflow-management system for TTP implementation.
  • Focus on the technical aspects of a TTP Dispatcher using open-source modules from the MOSAIC project.
  • Integration of identity management, pseudonym administration, and informed consent management functionalities.

Main Results:

  • The TTP Dispatcher concept enables mapping study-specific processes and requirements to workflows.
  • Workflows can be combined to model complex TTP processes, offering flexibility and extensibility.
  • Uniformity of the approach allows for unrestricted re-combination of functionalities across various research projects.

Conclusions:

  • The proposed workflow-driven TTP approach reduces scenario-specific implementation and maintenance efforts.
  • The concept's applicability and efficacy have been confirmed in nationwide studies, including the German Centre for Cardiovascular Research and the National Cohort.
  • This technical implementation provides a scalable and adaptable solution for managing sensitive research data securely and ethically.