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First-Line Antimicrobial Resistance Patterns of Escherichia coli in Children With Urinary Tract Infection in

M Nadeem Ahmed1, Debby Vannoy2, Ann Frederick2

  • 1Carle Foundation Hospital, Urbana, IL, USA University of Illinois College of Medicine, Urbana, IL, USA nadeem.ahmed@carle.com.

Clinical Pediatrics
|June 5, 2015
PubMed

Insights

Boys and children with genitourinary abnormalities face higher risks of antibiotic-resistant E. coli urinary tract infections (UTIs). Recent antibiotic use and age are also potential factors.

Area of Science:

  • Pediatric infectious diseases
  • Antimicrobial resistance
  • Urology

Background:

  • Urinary tract infections (UTIs) are common in children.
  • Antibiotic resistance in E. coli complicates UTI treatment.
  • Identifying risk factors is crucial for effective management.

Purpose of the Study:

  • To determine risk factors for antibiotic resistance in pediatric E. coli UTIs.
  • To inform clinical practice in emergency and primary care settings.

Main Methods:

  • Cross-sectional study design.
  • Systematic review of medical and laboratory records.
  • Inclusion of children aged 0-18 with E. coli-positive UTIs.

Main Results:

  • Boys showed increased resistance to ampicillin (2.29x) and trimethoprim-sulfamethoxazole (TMP/SMX) (2x) compared to girls.
  • Genitourinary abnormalities correlated with higher resistance to ampicillin (1.57x) and TMP/SMX (1.86x).

Conclusions:

  • Male sex and genitourinary abnormalities are significant risk factors for resistant E. coli UTIs.
  • Age and recent antibiotic prescriptions may also contribute to resistance patterns.
Abstract

Keywords:
Escherichia coliampicillinantibiotic resistanceantibioticscefazolinchildrenpediatricsrisk factorstrimethoprim-sulfamethoxazoleurinary tract infection

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