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Using a Comparative Species Approach to Investigate the Neurobiology of Paternal Responses
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Genetic approaches in comparative and evolutionary physiology.

Jay F Storz1, Jamie T Bridgham2, Scott A Kelly3

  • 1School of Biological Sciences, University of Nebraska, Lincoln, Nebraska; jstorz2@unl.edu.

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
|June 5, 2015
PubMed
Summary
This summary is machine-generated.

Quantitative genetics reveals how physiological performance evolves. Integrating genetic and field studies illuminates the adaptive significance of physiological variation and its underlying molecular mechanisms.

Keywords:
QTL mappingcomplex traitsphysiological genomicsselection experimentssystems genetics

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Area of Science:

  • Evolutionary biology
  • Physiological sciences
  • Quantitative genetics

Background:

  • Whole animal physiological performance and its underlying traits are polygenic and plastic.
  • Quantitative genetics offers a framework for analyzing physiological phenotypes and inferring microevolutionary processes.
  • Understanding physiological evolution requires integrating quantitative genetics, population genetics, and molecular evolution.

Purpose of the Study:

  • To review how quantitative genetics, population genetics, and molecular evolution inform physiological evolution.
  • To explore methods for characterizing the genetic architecture of physiological traits.
  • To highlight the role of organismal physiology in the synthesis of evolutionary biology.

Main Methods:

  • Analysis of intraspecific polymorphism and interspecific divergence for molecular mechanisms.
  • Integration of lab-based polygenic inheritance studies with field-based trait variation and survivorship studies.
  • Application of linkage mapping, association mapping, and systems approaches.
  • Utilizing population genomic approaches to infer adaptation.

Main Results:

  • Quantitative genetics can reveal molecular mechanisms and adaptive significance of physiological trait variation.
  • Lab and field studies can measure natural selection on physiological traits.
  • Selection experiments can probe trait interrelationships and the genetic basis of trade-offs.
  • Various genetic and systems approaches can dissect genotype-phenotype relationships.

Conclusions:

  • Integrating diverse methodologies provides comprehensive insights into physiological evolution.
  • Physiological variation has a significant genetic basis and is subject to natural selection.
  • Organismal physiology is central to a functional synthesis of evolutionary biology.