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Generation and Assembly of Virus-Specific Nucleocapsids of the Respiratory Syncytial Virus
Published on: July 27, 2021
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The nucleolar interface of RNA viruses
Stephen M Rawlinson1, Gregory W Moseley1
1Viral Pathogenesis Laboratory, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Australia.
Cellular Microbiology
|June 5, 2015
Summary
Viruses target the nucleolus, a dynamic cellular structure, for replication. This review explores how viruses, including cytoplasmic ones, interact with the nucleolus to manipulate host cells and advance their life cycle.
Area of Science:
- Cell Biology
- Virology
- Molecular Biology
Background:
- The nucleolus, traditionally known for ribosome biogenesis, is now recognized as a dynamic hub for diverse cellular functions.
- Viruses frequently interact with the nucleolus, impacting cellular processes and viral propagation.
Purpose of the Study:
- To review the emerging roles of virus-nucleolus interactions in viral life cycles and pathogenesis.
- To focus on cytoplasmic viruses that target the nucleolus, despite not replicating in the nucleus.
Main Methods:
- Literature review of recent studies on virus-nucleolus interactions.
- Analysis of examples linking nucleolar interactions to specific functional outcomes in viral infections.
Main Results:
- Nucleoli are implicated in various cellular functions beyond ribosome biogenesis.
- Many viruses, including nuclear and cytoplasmic types, interact with the nucleolus.
- Specific virus-nucleolus interactions are crucial for viral pathogenesis and replication.
Conclusions:
- Virus-nucleolus interactions represent a significant aspect of the virus-host interface.
- Understanding these interactions, especially for cytoplasmic viruses, is key to deciphering viral strategies.
- Further research is needed to fully resolve the molecular mechanisms underlying these interactions.
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