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Developmental changes in synaptic distribution in arcuate nucleus neurons.

Arian F Baquero¹, Melissa A Kirigiti², Karalee C Baquero²

¹Division of Diabetes, Obesity, & Metabolism, Oregon National Primate Research Center (ONPRC), Beaverton, Oregon 97006 baqueroa@ohsu.edu.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience

|June 5, 2015

Summary

This summary is machine-generated.

Synaptic inputs to hypothalamic neurons regulating feeding behavior change during development. GABAergic and glutamatergic connections to NAG neurons are reorganized, adapting to the animal

Keywords:

NAG neurons arcuate development obesity synaptic inputs

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Area of Science:

Neuroscience
Neuroendocrinology
Developmental Biology

Background:

Neurons coexpressing neuropeptide Y, agouti-related peptide, and GABA (NAG) are crucial for ingestive behavior.
NAG neurons in the arcuate nucleus receive GABAergic and glutamatergic inputs, but their developmental organization is unclear.

Purpose of the Study:

To investigate the developmental trajectory of synaptic input organization in mouse NAG neurons.
To understand how GABAergic and glutamatergic synapses change during postnatal development and in diet-induced obesity.

Main Methods:

Electrophysiological recordings in mouse models.
Analysis of GABAergic and glutamatergic synaptic inputs.
Comparison across different age groups and obesity states.

Main Results:

Early postnatal NAG neurons exhibit sparse GABAergic synapses, with GABA being inhibitory.
Glutamatergic inputs are abundant by P13 and similar to adult levels.
GABAergic tone increases in adulthood, with equal inhibitory and excitatory inputs.
Lean adult mice show reduced GABAergic synapses compared to younger adults.
Diet-induced obesity (DIO) mice exhibit reduced GABAergic and glutamatergic inputs.

Conclusions:

Synaptic organization of NAG neurons undergoes continuous restructuring throughout development.
These synaptic changes are likely adaptations to the animal's energy requirements.
Altered synaptic input patterns in DIO mice suggest a role in metabolic dysfunction.