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An updated role of microRNA-124 in central nervous system disorders: a review

Yang Sun1, Zhu-Min Luo1, Xiu-Ming Guo1

  • 1Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai China.

Frontiers in Cellular Neuroscience
|June 5, 2015
PubMed

Insights

MicroRNA-124 (miR-124), abundant in the brain, plays key roles in the central nervous system (CNS). Its dysregulation is linked to CNS disorders, offering therapeutic potential for brain diseases.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • MicroRNA-124 (miR-124) is the most abundant microRNA in the brain.
  • miR-124 biogenesis exhibits specific temporal and spatial expression patterns.
  • It influences diverse biological functions within the central nervous system (CNS).

Purpose of the Study:

  • To provide an overview of miR-124's molecular functions in the CNS.
  • To explore the therapeutic potential of miR-124 for human CNS diseases.

Main Methods:

  • Literature review and analysis of existing research on miR-124.
  • Synthesis of data on miR-124's role in various CNS conditions.

Main Results:

  • Dysregulation of miR-124 is associated with neurodegeneration, CNS stress, neuroimmune disorders, stroke, and brain tumors.
  • miR-124 has specific molecular functions critical for CNS health.

Conclusions:

  • miR-124 is a significant regulator of CNS biological functions.
  • Targeting miR-124 presents a promising therapeutic strategy for various human CNS diseases.
Keywords:
CNS disordersCNS stressbrain developmentbrain tumormicroRNA-124neurodegradationneuroimmunitystroke

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