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Functional status of thyroid and cognitive functions after menopause
Iwona Bojar1, Alfred Owoc2, Mariusz Gujski3
1Department for Health Problems of Ageing, Institute of Rural Health in Lublin, Lublin, Poland.
Summary
Thyroid function impacts cognitive health in postmenopausal women. Abnormal thyroid hormone levels (TSH, TT3, TT4) and antibodies (TPO-AB, AB-TSHR) correlated with poorer cognitive performance, highlighting the importance of thyroid health.
Area of Science:
- Endocrinology
- Neuroscience
- Gerontology
Background:
- Thyroid hormones significantly influence cognitive function.
- The relationship between subclinical thyroid dysfunction and cognitive changes in aging populations remains unclear.
- This study investigates thyroid function markers in postmenopausal women without clinical thyroid disease.
Purpose of the Study:
- To analyze cognitive function levels in relation to thyroid hormone levels and antibodies in postmenopausal women.
- To explore the association between thyroid-stimulating hormone (TSH), thyroxine (TT4), triiodothyronine (TT3), free thyroxine (FT4), free triiodothyronine (FT3), and thyroid antibodies (TPO-AB, Tg-AB, AB-TSHR) and cognitive performance.
- To identify potential links between thyroid status and neuropsychiatric changes in aging women.
Main Methods:
- Recruited 383 postmenopausal women (≥2 years post-menopause, no dementia signs).
- Assessed cognitive functions using the Central Nervous System Vital Signs (CNS VS) computerized battery.
- Measured plasma levels of TSH, FT3, FT4, TT3, TT4, TPO-AB, Tg-AB, and AB-TSHR; analyzed correlations using Pearson's coefficient and ANOVA.
Main Results:
- Thyroid-stimulating hormone (TSH) negatively correlated with NCI, executive functions, complex attention, and cognitive flexibility.
- Free thyroxine (FT4) positively correlated with psychomotor speed; TT3 and TT4 negatively correlated with memory and verbal memory.
- Thyroid antibodies (TPO-AB, Tg-AB, AB-TSHR) showed significant negative correlations with various cognitive domains, including memory, executive functions, and psychomotor speed.
Conclusions:
- Thyroid functionality is crucial for cognitive performance in postmenopausal women.
- Elevated TSH, TT3, TT4, TPO-AB, and AB-TSHR, along with lower FT4, were associated with poorer cognitive test results.
- These findings underscore the importance of monitoring thyroid health for maintaining cognitive function in aging women.
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