Related Experiment Video
Updated: Apr 11, 2026

Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations
Published on: July 24, 2021
[Comprehensive evaluation of drug interaction screening programs: discrepancies and concordances]
Anna Somogyi-Végh1, Bernadett Nyaka, Róbert György Vida
1Gyógyszerészeti Intézet és Klinikai Központi Gyógyszertár, Pécsi Tudományegyetem, Általános Orvostudományi Kar Pécs, Honvéd u. 3., 7624.
Introduction:
Recognition of potentially harmful drug interactions is one of the duties of healthcare. However, solutions involving databases are fraught with contradictions due to the lack of standardized principles and data.
Aim:
The aims of the authors were to perform a comparative evaluation of Hungarian and international databases and to explore ambiguities and contradictions in order to develop more standardized criteria for screening interactions.
Method:
Four Hungarian and two English-language websites and software, and the summaries of product characteristics were compared. The authors analyzed 40 drug-drug and 8 drug-supplement interactions and looked at 8 cases, which represent 28 pairs of interacting substances.
Results:
The databases warn about most interactions, but these warnings were rarely helpful in preventing undesired consequences. The authors found discrepancies between the databases in 70% of interactions. When looking at different products with the same active ingredients, discrepancies cropped up in 0-66.7% of the cases. Up to 80% of searches for supplementary product interactions did not produce satisfactory results.
Conclusions:
In the present situation mapping these ambiguities and creating a standardized classification system would be advantageous.
Related Concept Videos
Drug toxicity: Drug–Drug Interaction
Pharmacokinetics: Drug–Drug Interactions
Therapeutic Drug Monitoring: Drug Analysis Methods
Quantitative Aspects of Drug-Receptor Interaction
Pharmacovigilance
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
Pharmacokinetics: Drug–Food and Drug–Viral Interactions

