Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Somatic Spinal Reflexes

Somatic Spinal Reflexes

Somatic spinal reflexes are rapid, involuntary muscular responses to external stimuli that involve the somatic musculature and the spinal cord.
One of the most well-known somatic spinal reflexes is the stretch reflex, which is activated by the sudden stretching of a muscle. This reflex involves the activation of specialized sensory receptors called muscle spindles, which are located in the muscle tissue and detect changes in the length and speed of muscle contractions. When a muscle is suddenly...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Measurement Properties of 2 Novel PROs, the Pompe Disease Symptom Scale and Pompe Disease Impact Scale, in the COMET Study.

Neurology. Clinical practice·2023

Same author

Motor Responses in Pediatric Pompe Disease in the ADVANCE Participant Cohort.

Journal of neuromuscular diseases·2022

Same author

Cardiac responses in paediatric Pompe disease in the ADVANCE patient cohort.

Cardiology in the young·2021

Same author

Clinical characteristics and genotypes in the ADVANCE baseline data set, a comprehensive cohort of US children and adolescents with Pompe disease.

Genetics in medicine : official journal of the American College of Medical Genetics·2019

Same author

A placebo-controlled trial of simvastatin therapy in Smith-Lemli-Opitz syndrome.

Genetics in medicine : official journal of the American College of Medical Genetics·2016

Same author

ALG1-CDG: Clinical and Molecular Characterization of 39 Unreported Patients.

Human mutation·2016

Search research articles

Related Experiment Video

Updated: Apr 11, 2026

A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy

A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy

Published on: November 3, 2016

Neonatal hypotonia.

Susan E Sparks¹

¹Department of Pediatrics, Carolinas Healthcare System, 1000 Blythe Boulevard, Charlotte, NC 28203, USA.

Clinics in Perinatology

|June 5, 2015

Summary

This summary is machine-generated.

Neonatal hypotonia, a common NICU issue, has a broad genetic cause. An organized diagnostic approach using history, exam, and tests is crucial for prognosis and treatment.

Keywords:

Congenital Hypotonia Muscular dystrophy Myotonia Syndrome Weakness

More Related Videos

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

Neurodevelopmental Reflex Testing in Neonatal Rat Pups

Neurodevelopmental Reflex Testing in Neonatal Rat Pups

Published on: April 24, 2017

Related Experiment Videos

Last Updated: Apr 11, 2026

A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy

A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy

Published on: November 3, 2016

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

Neurodevelopmental Reflex Testing in Neonatal Rat Pups

Neurodevelopmental Reflex Testing in Neonatal Rat Pups

Published on: April 24, 2017

Area of Science:

Neonatology
Clinical Genetics
Pediatric Neurology

Background:

Neonatal hypotonia is a frequent challenge in neonatal intensive care units.
The differential diagnosis for neonatal hypotonia is extensive, including genetic disorders like muscular dystrophies, chromosomal abnormalities, neuropathies, and metabolic disorders.
While recognizing hypotonia is often simple, pinpointing its underlying cause can be complex.

Purpose of the Study:

To emphasize the importance of a systematic approach for neonatologists in assessing neonatal hypotonia.
To outline the key components of the diagnostic workup for neonatal hypotonia.
To highlight the significance of accurate diagnosis for patient outcomes and management.

Main Methods:

Review of clinical presentation and history.
Physical examination findings.
Basic laboratory investigations and imaging studies.

Main Results:

Hypotonia recognition is straightforward.
Diagnostic process involves integrating history, physical exam, and initial tests.
Identifying the etiology is key for prognosis, co-morbidities, and recurrence risk assessment.

Conclusions:

A structured diagnostic strategy is essential for managing neonatal hypotonia.
Early and accurate diagnosis guides therapeutic interventions and family counseling.
Multidisciplinary therapies, including physical, occupational, speech/feeding, and respiratory support, are the primary treatment modalities.