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Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

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Disorders of sexual development.

Bonnie McCann-Crosby¹, V Reid Sutton²

¹Division of Pediatric Endocrinology, Baylor College of Medicine, Texas Children's Hospital, 6701 Fannin Street, Houston, TX 77030, USA.

Clinics in Perinatology

|June 5, 2015

Summary

Disorders of sexual development (DSDs) involve a mismatch between genetic, hormonal, and anatomical sex. Prompt, multidisciplinary evaluation is crucial for diagnosis and infant care.

Keywords:

Ambiguous genitalia Disorders of sexual development (DSDs)Neonates Sex assignment

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Area of Science:

Pediatric Endocrinology
Genetics
Neonatology

Background:

Disorders of Sexual Development (DSDs) are characterized by discordance between chromosomal, gonadal, and anatomical sex.
These conditions often present as ambiguous genitalia in newborns, necessitating urgent medical assessment.
Accurate diagnosis is vital for appropriate infant management and sex assignment.

Purpose of the Study:

To review normal sexual development.
To present diagnostic algorithms for evaluating infants with ambiguous genitalia.
To outline conditions causing ambiguous genitalia in newborns.

Main Methods:

Literature review of normal sexual development.
Analysis of established diagnostic pathways for DSDs.
Compilation of common causes of ambiguous genitalia.

Main Results:

Normal sexual development follows a complex, genetically regulated pathway.
Diagnostic algorithms guide the systematic evaluation of ambiguous genitalia.
Various genetic, hormonal, and anatomical factors can lead to DSDs.

Conclusions:

Neonatologists must collaborate with multidisciplinary teams for DSD evaluation and management.
Early and accurate diagnosis of DSDs is essential for optimal infant outcomes.
Understanding normal sexual development aids in diagnosing and managing DSDs.