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Updated: Apr 11, 2026
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SUMO-Binding Entities SUBEs as Tools for the Enrichment, Isolation, Identification, and Characterization of the SUMO Proteome in Liver Cancer
Published on: November 1, 2019
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SUMO pathway components as possible cancer biomarkers
Domenico Mattoscio1, Susanna Chiocca1
11Department of Experimental Oncology, European Institute of Oncology@ IFOM-IEO Campus, Via Adamello 16, 20139 Milan, Italy.
Future Oncology (London, England)
|June 5, 2015
Summary
Small Ubiquitin-related MOdifier (SUMO)ylation is a critical cellular process. SUMO pathway alterations are linked to human cancers, suggesting potential as cancer biomarkers.
Area of Science:
- Biochemistry
- Molecular Biology
- Oncology
Background:
- SUMOylation is a crucial post-translational modification regulating cellular functions.
- The Small Ubiquitin-related MOdifier (SUMO) pathway plays a fundamental role in various biological processes.
- Dysregulation of SUMOylation is implicated in cellular dysfunction and disease pathology.
Purpose of the Study:
- To explore the link between the SUMO pathway and human malignancies.
- To investigate the role of SUMOylation in tumorigenesis.
- To discuss the potential of SUMO pathway components as cancer biomarkers.
Main Methods:
- Review of recent findings on SUMOylation in cancer.
- Analysis of the impact of SUMO pathway component alterations on cellular properties.
- Exploration of SUMO enzymes' role in predicting cancer behavior.
Main Results:
- Alterations in SUMO pathway components can subvert cellular properties, influencing proliferation, apoptosis resistance, and metastasis.
- A clear association between the SUMO pathway and human malignancies has been identified.
- SUMO enzymes show potential in predicting cancer progression and behavior.
Conclusions:
- The SUMO pathway is significantly involved in human tumorigenesis.
- SUMOylation is a key regulator of proteins implicated in carcinogenic pathways.
- Aberrations in SUMO pathway components may serve as valuable tumor biomarkers for cancer diagnosis and prognosis.
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