Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Analysis of trends and risk factors of HIV incidence in men who have sex with men in Chongqing, China: a retrospective cohort study, 2013-2022.

BMC infectious diseases·2026

Same author

A multifunctional eutectogel loaded with baicalein and MXene for diabetic infected wound healing under mild photothermal conditions.

Journal of materials chemistry. B·2026

Same author

Hierarchical Disruption of the Tryptophan-Melatonin Axis Contributes to Glioma Progression Through AKT/ERK/STAT3 Signalling.

Journal of cellular and molecular medicine·2026

Same author

Trimethylamine N-oxide drives cardiac aging by activating NLRP3-mediated pyroptosis.

Life sciences·2026

Same author

Selenium nanoparticle-loaded microneedle patches promote diabetic oral ulcer healing by regulating the inflammatory microenvironment through upregulation of SELENBP1-mediated mitophagy.

Journal of nanobiotechnology·2026

Same author

Research advances on protein-based microneedles for treatment of skin diseases: A review.

Materials today. Bio·2026

Same journal

Application of ephrin-B2 loaded glycol chitosan-silk fibroin hydrogel in the treatment of diabetic refractory wounds.

Scientific reports·2026

Same journal

International expert Delphi consensus on thromboprophylaxis in metabolic and bariatric surgery.

Scientific reports·2026

Same journal

Assessing the cross-region knowledge transfer capability of selected deep learning building vectorization methods in the context of available training datasets.

Scientific reports·2026

Same journal

Feasibility and preliminary effects of outdoor versus indoor cognitive-motor therapy in women with Alzheimer's disease: A randomized single-blind pilot study.

Scientific reports·2026

Same journal

Hallmarks of social action in the vocal turn-taking of wild common marmosets (Callithrix jacchus).

Scientific reports·2026

Same journal

Role and mechanism of AOPPs-induced NOX4-mediated ferroptosis in intervertebral disc degeneration.

Scientific reports·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Apr 11, 2026

Soft Lithographic Functionalization and Patterning Oxide-free Silicon and Germanium

Soft Lithographic Functionalization and Patterning Oxide-free Silicon and Germanium

Published on: December 16, 2011

Programming cancer through phase-functionalized silicon based biomaterials.

Priyatha Premnath¹, Krishnan Venkatakrishnan¹, Bo Tan²

¹Department of Mechanical and Industrial Engineering, Ryerson University, 350 Victoria Street, Toronto M5B2K3.

Scientific Reports

|June 5, 2015

Summary

This summary is machine-generated.

Researchers developed phase-functionalized silicon to selectively repel cancer cells without catalysts or additives. This novel biomaterial approach offers a new strategy for cancer therapy by controlling cell behavior and population.

More Related Videos

Functional Surface-immobilization of Genes Using Multistep Strand Displacement Lithography

Functional Surface-immobilization of Genes Using Multistep Strand Displacement Lithography

Published on: October 25, 2018

Preparation of Silicon Nanowire Field-effect Transistor for Chemical and Biosensing Applications

Preparation of Silicon Nanowire Field-effect Transistor for Chemical and Biosensing Applications

Published on: April 21, 2016

Related Experiment Videos

Last Updated: Apr 11, 2026

Soft Lithographic Functionalization and Patterning Oxide-free Silicon and Germanium

Soft Lithographic Functionalization and Patterning Oxide-free Silicon and Germanium

Published on: December 16, 2011

Functional Surface-immobilization of Genes Using Multistep Strand Displacement Lithography

Functional Surface-immobilization of Genes Using Multistep Strand Displacement Lithography

Published on: October 25, 2018

Preparation of Silicon Nanowire Field-effect Transistor for Chemical and Biosensing Applications

Preparation of Silicon Nanowire Field-effect Transistor for Chemical and Biosensing Applications

Published on: April 21, 2016

Area of Science:

Biomaterials Science
Nanotechnology
Cancer Research

Background:

Current biomaterial applications in cancer therapy are primarily limited to drug delivery and radiation markers.
A need exists for novel biomaterials that can directly interact with and influence cancer cell populations.

Purpose of the Study:

To introduce and investigate the concept of phase-functionalization of silicon for selective cancer cell repulsion.
To demonstrate a catalyst and additive-free approach for modifying silicon surfaces to control cancer cell behavior.

Main Methods:

Phase-functionalization of silicon using ultrafast laser pulses to create rare SiO2 phases and alter silicon crystal lattices.
Programming the degree of phase-functionalization to control cancer cell repulsion.
Characterizing the resulting changes in surface chemistry and surface energy of the functionalized silicon.

Main Results:

Successfully synthesized unstable silicon oxide phases, stable at ambient conditions, through phase-functionalization.
Demonstrated that phase-functionalized silicon precisely controls cancer cell migration, cytoskeleton shape, direction, and population.
Achieved cancer cell repulsion without altering surface topology or using additive layers.

Conclusions:

Phase-functionalized silicon offers a novel, programmable biomaterial for cancer therapy.
This approach has the potential to shift focus towards biomaterials as cancer-repelling or cancer-killing surfaces.
The technology represents a significant advancement in cancer research, distinct from existing applications.