Related Experiment Video

Updated: Apr 11, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

21.1K

Macro- and microvascular disease in systemic sclerosis

Niloufar Kavian1, Frédéric Batteux1

  • 1Faculté de Médecine Paris Descartes, Sorbonne Paris Cité, INSERM U 1016, Institut Cochin, Paris, France; Laboratoire d'immunologie biologique, Hôpital Cochin, Groupe Hospitalier Paris Centre, AP-HP, 75679 Paris cedex 14, France.

Vascular Pharmacology
|June 6, 2015
PubMed

Insights

Vasculopathy is a common issue in connective tissue diseases, particularly systemic sclerosis (SSc). This review details SSc-related vascular problems and their underlying disease mechanisms.

Area of Science:

  • Rheumatology
  • Vascular Medicine
  • Immunology

Background:

  • Connective tissue diseases frequently involve vasculopathy, impacting disease pathogenesis.
  • Systemic sclerosis (SSc) is an autoimmune disorder causing organ fibrosis and significant vascular disease.
  • Both micro- and macro-vessels are primary targets in SSc.

Purpose of the Study:

  • To review the clinical manifestations of vasculopathy in SSc patients.
  • To discuss the pathophysiology of vascular disorders in systemic sclerosis.

Main Methods:

  • Literature review of clinical manifestations.
  • Review of pathophysiological mechanisms of vascular damage.

Main Results:

  • Vasculopathy presents diverse clinical symptoms in SSc patients.
  • Pathophysiology involves direct targeting of blood vessels in SSc.
  • Fibrosis and autoimmune processes contribute to vascular complications.

Conclusions:

  • Vasculopathy is a key feature of systemic sclerosis, affecting various vessel types.
  • Understanding SSc-related vasculopathy is crucial for patient management.
  • Further research into pathophysiology can guide therapeutic strategies.

Keywords:
AngiogenesisEndo-mesenchymal transistionEndothelial cellsPericytesReactive oxygen speciesSystemic sclerosisVasculogenesisVasculopathy

More Related Videos

A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology09:33

A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology

Published on: February 7, 2015

17.0K
Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice08:09

Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice

Published on: March 24, 2017

8.7K

Related Concept Videos

Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
950
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
877
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
695
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
640
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
1.0K