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In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
Published on: July 24, 2020
Foveal pit morphology evaluation during optical biometry measurements using a full-eye-length swept-source OCT scan
Thomas Bertelmann1, Marcus Blum2, Kathleen Kunert2
1Department of Ophthalmology, Philipps-University Marburg, Marburg - Germany.
The new swept-source optical coherence tomography (SS-OCT) biometer prototype offers acceptable central retinal thickness (CRT) measurements for cataract surgery planning, though with lower resolution than spectral-domain OCT. Foveal pit morphology is discernible, aiding in patient examination.
Area of Science:
- Ophthalmology
- Medical Imaging
- Biometry
Background:
- Accurate biometric measurements are crucial for intraocular lens (IOL) power calculation in cataract surgery.
- Optical coherence tomography (OCT) is a key technology for assessing retinal structures.
- Swept-source OCT (SS-OCT) offers potential advantages in penetration depth and speed over spectral-domain OCT (SD-OCT).
Purpose of the Study:
- To evaluate the scan quality of foveal pit morphology (FPM) using a novel SS-OCT biometer prototype (IOLMaster700).
- To quantify central retinal thickness (CRT) measurements obtained with the SS-OCT biometer.
- To compare FPM and CRT results with those from a standard SD-OCT device (Cirrus4000).
Main Methods:
- 1 mm central horizontal retinal B-scans were acquired using the SS-OCT biometer prototype from phakic and pseudophakic eyes.
- Foveal pit morphology was subjectively assessed and compared between SS-OCT and SD-OCT techniques.
- Repeatability and accuracy of CRT measurements from the SS-OCT device were analyzed and compared to SD-OCT.
Main Results:
- The SS-OCT biometer's 1 mm retinal B-scan resolution was lower than SD-OCT, but advanced pathologic features were visible.
- Repeatability of CRT measurements with the SS-OCT showed an overall intraclass correlation of 0.57.
- CRT measurements differed significantly between the SS-OCT and SD-OCT in phakic eyes (group I).
Conclusions:
- The SS-OCT biometer provides acceptable, though not superior, repeatability and accuracy for CRT measurements compared to SD-OCT.
- The device's ability to discern FPM and pathologic characteristics is valuable for pre-operative assessment.
- This SS-OCT scan biometry holds potential for enhancing patient examination and surgical planning in cataract procedures.
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