Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Liver Regeneration

Liver Regeneration

The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Characterization of the genotypic and phenotypic spectrum of TCF7L2-related neurodevelopmental disorder (TRND).

Genetics in medicine : official journal of the American College of Medical Genetics·2026

Same author

The 2024 International Liver Transplant Society and International Liver Cancer Association Consensus Recommendations for Liver Transplantation for Liver Cancer.

Liver cancer·2026

Same author

Foundation models in computational pathology: methods, applications and clinical implications.

BMJ oncology·2026

Same author

Comparative Efficacy of Initial Treatment Strategies in Patients with Transarterial Chemoembolisation-Unsuitable Hepatocellular Carcinoma.

Liver cancer·2026

Same author

AGA Clinical Practice Update on Risk Stratification and Emerging Surveillance Strategies for Hepatocellular Carcinoma: Expert Review.

Gastroenterology·2026

Same author

Scientific, regulatory, and practical considerations for bringing hepatocellular carcinoma biomarkers into clinical practice.

JHEP reports : innovation in hepatology·2026

Search research articles

Related Experiment Video

Updated: Apr 11, 2026

Seven Steps to Stellate Cells

Seven Steps to Stellate Cells

Published on: May 10, 2011

A hepatic stellate cell gene expression signature associated with outcomes in hepatitis C cirrhosis and

David Y Zhang¹, Nicolas Goossens², Jinsheng Guo³

¹Department of Medicine, Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

|June 6, 2015

Summary

Researchers identified a 122-gene hepatic stellate cell signature that improves prognosis prediction in cirrhosis and hepatocellular carcinoma (HCC). This signature aids in identifying patients with poor outcomes, offering potential targets for treatment.

Keywords:

HEPATIC FIBROSIS HEPATIC STELLATE CELL LIVER CIRRHOSIS LIVER FAILURE

More Related Videos

Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis

Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis

Published on: April 12, 2024

Isolation of Regenerating Hepatocytes after Partial Hepatectomy in Mice

Isolation of Regenerating Hepatocytes after Partial Hepatectomy in Mice

Published on: December 2, 2022

Related Experiment Videos

Last Updated: Apr 11, 2026

Seven Steps to Stellate Cells

Seven Steps to Stellate Cells

Published on: May 10, 2011

Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis

Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis

Published on: April 12, 2024

Isolation of Regenerating Hepatocytes after Partial Hepatectomy in Mice

Isolation of Regenerating Hepatocytes after Partial Hepatectomy in Mice

Published on: December 2, 2022

Area of Science:

Bioinformatics
Genomics
Hepatology

Background:

Hepatic stellate cells (HSCs) play a crucial role in liver fibrosis and hepatocellular carcinoma (HCC).
Identifying unique HSC markers is essential for understanding liver disease progression and developing targeted therapies.

Purpose of the Study:

To identify and validate genes uniquely expressed in hepatic stellate cells.
To assess the prognostic capability of HSC gene expression in cirrhosis and HCC.

Main Methods:

An informatics approach was used to define an HSC gene signature by comparing transcriptome profiles.
A prognostic index was developed using the HSC signature and clinical variables.
The signature and index were derived and validated in independent cohorts of cirrhosis and HCC patients.

Main Results:

A 122-gene HSC signature, comprising genes for extracellular matrix proteins and developmental factors, was identified.
This signature correlated with fibrosis extent across species and improved overall survival prediction when combined with clinical variables.
The derived prognostic index accurately predicted overall survival, decompensation, HCC development, and progression in cirrhosis patients, and HCC recurrence in HCC patients.

Conclusions:

The study highlights the unique transcriptional profile of hepatic stellate cells.
The identified HSC signature can potentially identify patients with HCV cirrhosis or postresection HCC who have a poor prognosis.
The findings suggest potential targets for tracking, targeting, and isolating hepatic stellate cells.