Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

948
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
948
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

922
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
922
Bile01:19

Bile

6.2K
Bile is a crucial bodily fluid, characterized by its yellow-green color and alkaline nature. Produced in the liver, it is transported through the common hepatic duct into either the cystic duct, leading to the gallbladder, or directly into the common bile duct. The flow of bile is regulated by the sphincter of Oddi located at the entrance of the duodenum. When this sphincter is closed, bile is redirected to the gallbladder for storage and concentration.
Bile is released when dietary fats enter...
6.2K
Hepatic Drug Excretion: Influencing Factors01:16

Hepatic Drug Excretion: Influencing Factors

765
The biliary system of the liver, crucial for bile secretion and drug excretion, comprises intrahepatic bile ducts that merge to form the common hepatic duct. This duct, carrying hepatic bile, combines with the cystic duct, draining the gallbladder and forming the common bile duct, which empties into the duodenum. Bile, produced by hepatic cells lining the bile canaliculi, is composed primarily of water, bile salts, pigments, electrolytes, and lesser amounts of cholesterol and fatty acids. Bile...
765
Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

1.1K
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
1.1K
Hepatic Drug Excretion: Enterohepatic Cycling01:17

Hepatic Drug Excretion: Enterohepatic Cycling

3.4K
Enterohepatic cycling involves the active secretion of drugs and their metabolites into the bile via transporters in the canalicular membrane of hepatocytes. This secretion is an integral part of the digestive process, releasing these substances into the gastrointestinal (GI) tract.
Post-release drugs and metabolites can be reabsorbed into the body from the intestine. For conjugated metabolites like glucuronides, reabsorption requires enzymatic hydrolysis by intestinal microflora. This...
3.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Consensus paper for the standardized laboratory diagnostics of chronic kidney disease (CKD) in the context of cardiovascular-renal-metabolic health (ÖGLMKC, ÖQUASTA, ÖGN) : Consensus paper of the Austrian Society for Laboratory Medicine and Clinical Chemistry (ÖGLMKC), the Austrian Society for Quality Assurance and Standardization of Medical Diagnostic Examinations (ÖQUASTA), and the Austrian Society for Nephrology (ÖGN)].

Wiener klinische Wochenschrift·2026
Same author

[Diabetic kidney disease (Update 2026) : Guidelines in a collaboration of the Austrian Diabetes Association and the Austrian Society of Nephrology].

Wiener klinische Wochenschrift·2026
Same author

Case Report: COVID-19 unmasks factor H mutation-driven hemolytic uremic syndrome in a previously undiagnosed septuagenarian kidney transplant recipient.

Frontiers in medicine·2026
Same author

Effects of Immunoadsorption on Markers of Iron Metabolism: A Case Series.

Journal of clinical apheresis·2026
Same author

Revisiting clinical response and refractoriness in immune thrombotic thrombocytopenic purpura.

Blood·2026
Same author

Randomized controlled trials in Europe: a call to action to protect national healthcare systems from the upcoming tsunami of kidney failure.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2026

Related Experiment Video

Updated: Apr 11, 2026

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
08:56

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis

Published on: February 10, 2015

55.4K

Bile acid-induced cholemic nephropathy.

Elisabeth Krones1, Martin Wagner, Kathrin Eller

  • 1Research Unit for Experimental and Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.

Digestive Diseases (Basel, Switzerland)
|June 6, 2015
PubMed
Summary
This summary is machine-generated.

Cholemic nephropathy, or kidney injury in jaundiced patients, is an underestimated cause of kidney dysfunction in advanced liver disease. This review clarifies its characteristics, mechanisms, and future diagnostic and therapeutic strategies.

More Related Videos

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
06:35

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice

Published on: June 28, 2021

4.7K
Partial Bile Duct Ligation in the Mouse: A Controlled Model of Localized Obstructive Cholestasis
04:38

Partial Bile Duct Ligation in the Mouse: A Controlled Model of Localized Obstructive Cholestasis

Published on: March 28, 2018

16.8K

Related Experiment Videos

Last Updated: Apr 11, 2026

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
08:56

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis

Published on: February 10, 2015

55.4K
Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
06:35

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice

Published on: June 28, 2021

4.7K
Partial Bile Duct Ligation in the Mouse: A Controlled Model of Localized Obstructive Cholestasis
04:38

Partial Bile Duct Ligation in the Mouse: A Controlled Model of Localized Obstructive Cholestasis

Published on: March 28, 2018

16.8K

Area of Science:

  • Nephrology
  • Hepatology
  • Pathology

Background:

  • Cholemic nephropathy describes kidney injury in jaundiced patients, characterized by impaired renal function and specific histomorphological changes.
  • It is an underrecognized cause of kidney dysfunction in cholestasis and advanced liver disease.
  • Current understanding is limited by inconsistent nomenclature, unclear mechanisms, and lack of diagnostic criteria.

Purpose of the Study:

  • To summarize current knowledge on cholemic nephropathy.
  • To outline clinical and morphological features.
  • To discuss preclinical models, pathomechanisms, and future diagnostic and therapeutic strategies.

Main Methods:

  • Literature review and synthesis of existing research.
  • Analysis of clinical and histopathological findings.
  • Discussion of preclinical models and potential pathomechanisms.

Main Results:

  • Cholemic nephropathy involves tubular injury and cast formation in jaundiced patients with liver disease.
  • Mechanisms remain unclear, hindering standardized diagnosis and treatment.
  • The review consolidates information on characteristics and potential therapeutic targets.

Conclusions:

  • Cholemic nephropathy is a significant clinical entity requiring further research.
  • Standardized diagnostic criteria and therapeutic approaches are needed.
  • Future research should focus on elucidating mechanisms and developing targeted interventions.