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Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
Published on: June 28, 2021
[Drug-induced pancreatitis. A review of French spontaneous reports]
L Chebane1, H Bagheri1, D Hillaire-Buys2
1Laboratoire de pharmacologie médicale et clinique, centre de Midi-Pyrénées de pharmacovigilance, de pharmaco-épidémiologie et d'informations sur le médicament, équipe de pharmaco-épidémiologie de l'UMR, Inserm U1027, CHU de Toulouse, faculté de médecine, université de Toulouse, 37, allées Jules-Guesde, 31000 Toulouse, France.
Purpose:
Identify the main pharmacological classes inducing pancreatitis using spontaneous reports recorded in the French pharmacovigilance database (FPVD).
Methods:
Cases of pancreatitis recorded in FPVD between January 1st 1985 and December 31st 2013 were selected using the 2001 consensus conference criteria of the French High Health Authority.
Results:
During this period, 2975 observations were selected with 1151 fulfilling criteria of drug-induced pancreatitis (i.e. 0.22% of total notifications in the FPVD). According to ATC classification, the pharmacological classes most frequently found were antiretroviral, analgesic, lipid-lowering, immunosuppressive and insulin secreting drugs. For some drugs (metformin, omeprazole, etc.) pancreatitis was "unlabelled" in the summary of product characteristics.
Conclusion:
This review allows to identify the main drug classes currently involved in spontaneous reporting of pancreatitis in France.
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